# Carbohydrate mediated drug delivery: Synthesis and characterization of new lipid-conjugates

## TL;DR

This paper presents a new method to create lipid-drug carriers that target specific receptors using carbohydrates, tested for gene delivery in cells.

## Contribution

A novel synthetic approach for cationic glycolipids with potential for targeted drug delivery is introduced.

## Key findings

- PAPM and PAPG lipid conjugates were successfully synthesized for drug targeting.
- Compound 1a showed binding inhibition with Concanavalin A using invertase enzyme.
- The lipid conjugates were tested for gene transfection in A549 cells.

## Abstract

A new synthetic methodology for cationic glycolipids using p-aminophenyl-α-d-mannopyranoside (PAPM), p-aminophenyl-α-d-galactopyranoside (PAPG) was developed. PAPM-lipids and PAPG-lipids conjugates were also synthesized for targeting drugs to receptors. A binding inhibition study of synthesized p-(dimethylamino butylamido) phenyl-α-d-mannopyranoside (1a) with Concanavalin A was performed using invertase enzyme. In addition, transfection of pSV-β-gal reporter gene with was investigated in A549 cells.