# Transient Global Amnesia as the First Clinical Symptom for Malignant B-Cell Lymphoma with Central Nervous System Involvement **Authors:** Atif Zafar, Ghulam Ishaq Khan, Sahrish Abdin, Muhammad Taimoor Khan PMC · DOI: 10.1155/2015/191709 · Case Reports in Neurological Medicine · 2015-07-07 ## TL;DR An elderly man's first symptom of a rare brain-related lymphoma was transient global amnesia, a previously unreported case in medical literature. ## Contribution This is the first documented case linking B-cell lymphoma with central nervous system involvement to transient global amnesia as an initial symptom. ## Key findings - Transient global amnesia can be the first sign of malignant B-cell lymphoma with CNS involvement. - Imaging protocols for TGA should consider underlying neurological malignancies. - Early detection of lymphoma through TGA symptoms may improve diagnostic accuracy. ## Abstract We present the case of an elderly male who was diagnosed with transient global amnesia (TGA), only to be diagnosed with B-cell lymphoma with central nervous system involvement a few weeks later. This is the first ever case reported in literature with lymphoma presenting as TGA. Literature review and pertinent points regarding high-yield imaging protocol for presumed TGA patients are discussed. ## Linked entities - **Diseases:** transient global amnesia (MONDO:0001617), B-cell lymphoma (MONDO:0015759) ## Full-text entities - **Diseases:** migraines (MESH:D008881), tongue bite (MESH:D014060), lymphoma (MESH:D008223), leukemia (MESH:D007938), Epileptic features (OMIM:600512), dementia (MESH:D003704), TGA (MESH:D020236), seizure (MESH:D012640), epilepsy (MESH:D004827), weakness (MESH:D018908), left sided weakness (MESH:C537001), metastatic tumors (MESH:D009369), Amnesia (MESH:D000647), facial droop (MESH:D005153), Central Nervous System Involvement (MESH:C538190), memory impairment (MESH:D008569), retrograde amnesia (MESH:D000648), loss of consciousness (MESH:D014474), meningioma (MESH:D008579), B-cell lymphoma (MESH:D016393), anterograde amnesia (MESH:D020324), neurological conditions (MESH:D019636), dysarthria (MESH:D004401), encephalopathy (MESH:D001927), fatigue (MESH:D005221), neurological symptoms (MESH:D009461), incontinence (MESH:D014549), TIAs (MESH:D002546), cognitive impairment (MESH:D003072), heart disease (MESH:D006331), stroke (MESH:D020521), amnestic syndromes (MESH:D000425), head injury (MESH:D006259), Posterior reversible encephalopathy syndrome (MESH:D054038), hypertension (MESH:D006973), PAF (MESH:D001281), confusion (MESH:D003221) - **Chemicals:** B12 (MESH:C034730), alcohol (MESH:D000438) - **Species:** Nicotiana tabacum (American tobacco, species) [taxon 4097], Homo sapiens (human, species) [taxon 9606] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC4508470/full.md ## Figures 1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC4508470/full.md ## References 9 references — full list in the complete paper: https://tomesphere.com/paper/PMC4508470/full.md --- Source: https://tomesphere.com/paper/PMC4508470