# LK or IGF1R: When selectivity hurts

**Authors:** Igor Puzanov, Alexandra Hess

PMC · DOI: 10.18632/aging.100753 · Aging (Albany NY) · 2015-05-30

## Full-text entities

- **Genes:** GH1 (growth hormone 1) [NCBI Gene 2688] {aka GH, GH-N, GHB5, GHN, IGHD1A, IGHD1B}, INSR (insulin receptor) [NCBI Gene 3643] {aka CD220, HHF5}, INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, TXK (TXK tyrosine kinase) [NCBI Gene 7294] {aka BTKL, PSCTK5, PTK4, RLK, TKL}, IGF1R (insulin like growth factor 1 receptor) [NCBI Gene 3480] {aka CD221, IGFIR, IGFR, JTK13}, IGF1 (insulin like growth factor 1) [NCBI Gene 3479] {aka IGF, IGF-I, IGFI, MGF}, IGF2 (insulin like growth factor 2) [NCBI Gene 3481] {aka C11orf43, GRDF, IGF-II, PP9974, SRS3}, ALK (ALK receptor tyrosine kinase) [NCBI Gene 238] {aka ALK1, CD246, NBLST3}
- **Diseases:** insulin resistance (MESH:D007333), type 2 diabetes mellitus (MESH:D003924), metastasis (MESH:D009362), cancer (MESH:D009369), diabetes (MESH:D003920), obesity (MESH:D009765), colorectal cancer (MESH:D015179), adrenocortical carcinoma (MESH:D018268), IR (MESH:C562709), lung cancer (MESH:D008175)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC4505153/full.md

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Source: https://tomesphere.com/paper/PMC4505153