# Selective Reduction of THC’s Unwanted Effects through Serotonin Receptor Inhibition

**Authors:** Richard Robinson

PMC · DOI: 10.1371/journal.pbio.1002193 · PLoS Biology · 2015-07-09

## TL;DR

Researchers found a way to reduce harmful effects of cannabis on memory while keeping its pain benefits by targeting specific brain receptors.

## Contribution

The study identifies a receptor partnership that causes harmful effects of THC and suggests pharmaceutical strategies to inhibit it.

## Key findings

- THC's harmful effects on memory are mediated by a partnership between cannabinoid and serotonin receptors.
- Pharmaceutical inhibition of serotonin receptors may selectively reduce THC's unwanted effects.
- This finding opens new possibilities for safer cannabis-based pain treatments.

## Abstract

How can we harness the beneficial effects of cannabis on pain without the harmful effects on memory? A new study shows that the harmful effects are specifically mediated by a partnership between cannabinoid and serotonin receptors, with pharmaceutical implications.

## Linked entities

- **Chemicals:** THC (PubChem CID 16078)

## Full-text entities

- **Genes:** Htr2a (5-hydroxytryptamine (serotonin) receptor 2A) [NCBI Gene 15558] {aka 5-HT-2, 5-HT-2A, E030013E04, Htr-2, Htr2}, Cnr1 (cannabinoid receptor 1) [NCBI Gene 12801] {aka CB-R, CB1, CB1A, CB1B, CB1R}
- **Diseases:** hypothermia (MESH:D007035), anxiety (MESH:D001007), analgesia (MESH:D000699), impairment of memory (MESH:D008569), amnesic (MESH:D000647), pain (MESH:D010146), nausea (MESH:D009325),  (MESH:D003072)
- **Chemicals:** lipids (MESH:D008055), serotonin (MESH:D012701), THC (MESH:D013759), endocannabinoid (MESH:D063388)
- **Species:** Mus musculus (house mouse, species) [taxon 10090]

## Full text

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## Figures

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## References

1 references — full list in the complete paper: https://tomesphere.com/paper/PMC4497641/full.md

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Source: https://tomesphere.com/paper/PMC4497641