# Investigating Factors Associated with Depression of Type 2 Diabetic Retinopathy Patients in China

**Authors:** Xujuan Xu, Xiaoyan Zhao, Duo Qian, Qing Dong, Zhifeng Gu

PMC · DOI: 10.1371/journal.pone.0132616 · 2015-07-07

## TL;DR

This study found that over a third of type 2 diabetic retinopathy patients in Nantong, China, experience depression, with factors like gender, income, vision, and treatment history playing a role.

## Contribution

The study identifies specific risk factors for depression in a Chinese type 2 diabetic retinopathy population.

## Key findings

- 35.7% of patients reported depressive symptoms.
- Female gender, low income, poor vision, and laser treatment history were significant risk factors for depression.
- Quality of life was significantly better for those with lower CES-D scores.

## Abstract

To assess the depression status of type 2 diabetic retinopathy patients in Nantong China and to identify factors associated with depression.

Two hundred and ninety-four patients with type 2 diabetic retinopathy were recruited from the Affiliated Hospital of Nantong University. The severity of DR was measured in the worse eye. Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale (CES-D); the quality of life was measured with the Medical Outcomes Study Short Form 36 (SF-36). The logistic regression analyses were used to identify the independent factors of depression.

The mean age of the study subjects was 57.77 years (SD: 9.64). Approximately 35.7% of subjects reported depressive symptoms (n = 105).Multiple logistic regression analyses showed that female gender (p = 0.014), low monthly income (p = 0.01), poor vision in the better eye (P = 0.002), laser treatment history (p = 0.01) were significant risk factors for depression. The quality of life of individuals with CES-D score<16 was significantly better compared with individuals with CES-D score≥16.

The reported depressive symptoms among type 2 diabetic retinopathy population is higher in Nantong China. Gender, salary, vision acuity and treatment history were important risk factors linked to this disorder in the Chinese type 2 diabetic retinopathy population from Nantong. More attention by medical care personnel needs to be paid to the psychological health of this population.

## Linked entities

- **Diseases:** depression (MONDO:0002050)

## Full-text entities

- **Genes:** INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}
- **Diseases:** BP (MESH:D010146), suicidal ideation (MESH:D001072), minor depression (MESH:D004832), DR (MESH:D003930), RP (MESH:D012174), fatigue (MESH:D005221), RE (MESH:C535499), blindness (MESH:D001766), renal failure (MESH:D051437), glaucoma (MESH:D005901), type 2 diabetes (MESH:D003924), poor vision (MESH:D014786), mood symptoms (MESH:D019964), Center (MESH:D008224), PF (MESH:D059445), emotional problems (MESH:D019973), hypertension (MESH:D006973), diabetes (MESH:D003920), CES (MESH:C535918), diabetes complications (MESH:D048909), Depression (MESH:D003866), Non proliferative diabetic retinopathy (OMIM:603933), major depression (MESH:D003865), DR (MESH:D004370), anxiety (MESH:D001007), cancer (MESH:D009369), PDR (MESH:C564461), MH (OMIM:603663), hearing and cognitive impairment (MESH:D003072)
- **Chemicals:** blood glucose (MESH:D001786), glucose (MESH:D005947)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC4494704/full.md

---
Source: https://tomesphere.com/paper/PMC4494704