# Far from Membranes, BEACH Domains Regulate Stress-Related mRNAs

**Authors:** Richard Robinson

PMC · DOI: 10.1371/journal.pbio.1002189 · PLoS Biology · 2015-07-02

## TL;DR

A plant protein previously linked to membranes was found to help control mRNA stability during salt stress, suggesting similar roles in other organisms.

## Contribution

The study reveals a new role for BEACH domain-containing proteins in regulating stress-related mRNAs, beyond their known membrane functions.

## Key findings

- A plant BEACH domain-containing protein regulates transcript stability under salt stress.
- This function may be conserved in BDCPs across different organisms.
- The findings challenge the traditional view of BDCPs being solely involved in membrane dynamics.

## Abstract

BEACH domain-containing proteins (BDCPs) were thought to be involved in membrane dynamics, but a new study reveals that a plant BDCP helps to regulate transcript stability in response to salt stress, and BDCPs in other organisms may play a similar role.

## Linked entities

- **Chemicals:** salt (PubChem CID 5234)

## Full-text entities

- **Genes:** SPI (BEACH-DOMAIN HOMOLOG A1) [NCBI Gene 839323] {aka F10O3.12, F10O3_12, SPIRRIG}, NBEAL1 (neurobeachin like 1) [NCBI Gene 65065] {aka A530083I02Rik, ALS2CR16, ALS2CR17}, DCP1 (decapping 1) [NCBI Gene 837357] {aka ATDCP1, decapping 1}
- **Diseases:** salt stress hypersensitivity (MESH:D013651)
- **Species:** Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932], Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090], Arabidopsis thaliana (mouse-ear cress, species) [taxon 3702]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC4489839/full.md

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC4489839/full.md

## References

1 references — full list in the complete paper: https://tomesphere.com/paper/PMC4489839/full.md

---
Source: https://tomesphere.com/paper/PMC4489839