# Reply to “Comment on ‘De Novo Reconstruction of 3D Human Facial Images From DNA Sequence’”

## TL;DR

This paper responds to a comment on a study that reconstructs 3D human facial images from DNA, clarifying methods and addressing misconceptions.

## Contribution

The paper clarifies the methodology and limitations of DNA-based 3D facial prediction and discusses ethical considerations.

## Key findings

- The original study's methodological rationale and analytical procedures are clarified.
- Misconceptions in the Comment by Wagner et al. are addressed.
- Ongoing efforts to improve DNA-based facial prediction are highlighted.

## Abstract

This manuscript is a formal response to the Comment by Wagner et al. regarding our publication “De Novo Reconstruction of 3D Human Facial Images from DNA Sequence.” We clarify the methodological rationale, analytical procedures, and scientific scope of our original study, and we address several misconceptions arising in the Comment. We further highlight the intended purpose and limitations of Difface and discuss ongoing efforts to advance the rigor, interpretability, and ethical governance of DNA‐based 3D facial prediction.