# Transcatheter edge-to-edge repair for severe mitral regurgitation in a patient with a massive left atrium: a case report

## TL;DR

A 77-year-old man with a very large left atrium successfully underwent a heart repair procedure that is typically considered unsuitable for such cases.

## Contribution

This case shows that TEER can be effective in patients with extreme left atrium enlargement, challenging standard anatomical criteria.

## Key findings

- TEER was successfully performed in a patient with a massive left atrium (113 × 129 × 133 mm).
- Three MitraClip devices were deployed, resulting in mild residual mitral regurgitation and a mean gradient of 5 mmHg.
- The patient showed left atrial reverse remodelling and symptomatic improvement after one month.

## Abstract

Transcatheter edge-to-edge repair (TEER) poses significant technical challenges in patients with a massive left atrium (LA), where conventional anatomical criteria often deem the procedure unsuitable.

A 77-year-old man, at prohibitive surgical risk, presented with a giant LA (113 × 129 × 133 mm) and severe mitral regurgitation (MR). After pacemaker implantation, TEER was performed. Despite suboptimal echocardiographic windows and challenging leaflet capture, a tailored posteroinferior transseptal puncture 4.67 cm above the mitral annular plane provided a stable trajectory, enabling successful navigation and deployment of three MitraClip devices (Abbott, Santa Clara, CA, USA). The procedure achieved an excellent outcome with a mean gradient of 5 mmHg and only mild residual MR. Marked left atrial reverse remodelling and symptomatic improvement were observed at 1-month follow-up.

This case demonstrates that TEER is a viable and effective intervention for patients with extreme LA enlargement, challenging conventional anatomical selection criteria. Success hinges on technical precision—particularly an optimized transseptal puncture—and prioritizing favourable haemodynamic outcomes over rigid anatomic thresholds.