# Silent but present: a case of Chagas disease-related megaoesophagus diagnosed in a non-endemic setting

**Authors:** Virginia Donini, Anna Barbiero, Michele Spinicci, Fabio Marra, Francesco Vizzutti, Damiano Bisogni, Gian Maria Rossolini, Francesca Malentacchi, Lorenzo Zammarchi, Alessandro Bartoloni

PMC · DOI: 10.1093/jtm/taag014 · Journal of Travel Medicine · 2026-02-12

## TL;DR

A case of Chagas disease-related megaoesophagus is reported in a non-endemic country, emphasizing the need for awareness in at-risk migrants.

## Contribution

Highlights the first reported case of CD-related megaoesophagus in a non-endemic setting in Europe.

## Key findings

- CD-related megaoesophagus can occur in non-endemic countries due to migration.
- The patient had lived in Italy for 14 years before diagnosis, showing the disease's silent progression.
- The case underscores the importance of considering CD in at-risk individuals with gastrointestinal symptoms.

## Abstract

Due to migration phenomena, Chagas disease (CD) is emerging in Europe, where CD-related gastrointestinal complications are rarely reported. We describe a case of CD-related megaoesophagus in a patient from El Salvador, in Italy since 14 years, highlighting the importance of considering complicated CD in patients at risk with suggestive symptoms.

## Linked entities

- **Diseases:** Chagas disease (MONDO:0001444)

## Full-text entities

- **Diseases:** megaesophagus (MESH:D004931), gastrointestinal complications (MESH:D005767), CD (MESH:D014355)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC13042230/full.md

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Source: https://tomesphere.com/paper/PMC13042230