# Small noncoding RNA TY2 enhances efferocytosis and improves outcomes in a mouse model of sepsis

**Authors:** Alessandra Ciullo, Xaviar M. Jones, Hiroaki Komuro, Liang Li, Anh Nguyen, Eduardo Marbán, Ahmed Gamal-Eldin Ibrahim

PMC · DOI: 10.1172/jci.insight.196153 · JCI Insight · 2026-01-22

## TL;DR

TY2, a natural compound, reduces inflammation and improves survival in mice with severe bacterial infections.

## Contribution

TY2 is shown to enhance efferocytosis and improve sepsis outcomes in a mouse model.

## Key findings

- TY2 improves outcomes in mice with severe bacterial infection.
- TY2 has potent anti-inflammatory effects.

## Abstract

TY2 is a drug based on a natural compound with potent anti-inflammatory effects. TY2 improved outcomes in mice with severe bacterial infection.

## Linked entities

- **Species:** Mus musculus (taxon 10090)

## Full-text entities

- **Diseases:** sepsis (MESH:D018805)
- **Species:** Mus musculus (house mouse, species) [taxon 10090]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC13041665/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC13041665/full.md

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Source: https://tomesphere.com/paper/PMC13041665