# Clinical outcomes with oral cephalosporins as definitive treatment of Enterobacterales bacteremia from a urinary source based on cefazolin minimum inhibitory concentration

## TL;DR

This study found that oral cephalosporins effectively treat blood infections from urinary sources, regardless of antibiotic resistance levels.

## Contribution

The study explores treatment outcomes using cefazolin minimum inhibitory concentration for oral cephalosporin therapy in bacteremia.

## Key findings

- No difference in 30-day treatment outcomes was found based on cefazolin minimum inhibitory concentration.
- Oral cephalosporins were effective for treating bacteremia from urinary sources in patients with E. coli, K. pneumoniae, or P. mirabilis.

## Abstract

Cefazolin breakpoints differ for the treatment of Enterobacterales urinary tract infections and systemic infections. A retrospective, exploratory cohort study of 148 patients found no difference in 30-day treatment outcomes based on the blood culture cefazolin minimum inhibitory concentration (≤2 mcg/mL versus 4–16 mcg/mL) for patients transitioned to PO cephalosporins for the treatment of Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis bacteremia secondary to a urinary source. Further research should confirm these findings.