# Modified Framingham stroke risk profile and related research on uric acid in individuals aged over 65 years in the Yangtze River Delta region, China

## TL;DR

This study assesses stroke risk in older adults in China's Yangtze River Delta region and finds that higher uric acid levels are linked to increased stroke risk.

## Contribution

The study introduces a modified Framingham Stroke Profile for older adults and identifies uric acid as a potential predictor of stroke risk in this population.

## Key findings

- 51.0% of participants were classified as low stroke risk, 43.6% as medium, and 5.4% as high.
- Uric acid levels were positively correlated with stroke risk scores (r = 0.135).
- Peripheral blood uric acid showed limited predictive value for high stroke risk (AUC = 0.611).

## Abstract

With socioeconomic advancement stroke has garnered extensive public attention.

This study aimed to assess the 10-year risk of stroke among individuals aged over 65 years within a community utilizing the modified Framingham Stroke Profile (FSP). Additionally, the characteristics of high-risk factors for stroke and their associations with peripheral blood uric acid levels (UA) were explored.

A cross-sectional stratified survey method was employed, adhering to the principles of stratified sampling. Between February and October 2020, residents from seven community committees in the Suzhou High-tech Zone were selected to participate in questionnaire surveys and undergo blood biomarker testing to evaluate the 10-year stroke risk of stroke using the modified FSP.

According to the population-based modified FSP risk assessment, 823 individuals (51.0%) were classified as low risk, 703 individuals (43.6%) as medium risk, and 87 individuals (5.4%) as high risk. Peripheral blood uric acid levels were positively correlated with the 10-year stroke risk score (r = 0.135). Logistic regression analysis identified several risk factors for modified FSP medium-high risk in the community-dwelling population aged over 65 years, comprising male sex, age, hyperlipidemia, and hyperuricemia in Q4. Moreover, receiver operating characteristic (ROC) curve analysis identified peripheral blood uric acid level as a potential predictor of high stroke risk, with an area under the ROC curve (AUC) of 0.611 (medium+high vs. low). Lastly, the optimal diagnostic threshold was 292.5 μmol/L (approximately 4.92 mg/dL).

The stroke risk profile in this region warrants serious consideration. Elevated levels of uric acid (UA) are associated with increased modified FSP risk. Consequently, peripheral uric acid may serve as a limited indicator for discriminating medium-to-high modified FSP risk.