# SASdb: a comprehensive database for sex-biased alternative splicing profiles in human tissues

## TL;DR

SASdb is a new database that catalogs sex-biased alternative splicing events across 22 human tissues, offering insights into molecular sex differences and disease-related pathways.

## Contribution

SASdb is the first comprehensive database to systematically compile sex-related alternative splicing events across multiple human tissues.

## Key findings

- SASdb contains 46,418 sex-biased alternative splicing events across 22 human tissues.
- NSCLC-specific SAS events are enriched in cancer-related pathways such as autophagy and AMPK/mTOR signaling.
- The database provides intuitive visualization tools to support research in sex biology and precision medicine.

## Abstract

Alternative splicing (AS) significantly enhances transcriptomic diversity, and its dysregulation is implicated in numerous human diseases. However, no public database systematically compiles sex-related AS events across human tissues. We developed SASdb (http://www.gdbioinfo.top/sasdb), a comprehensive database contains 2,951,059 AS events and 46,418 sex-biased alternative splicing (SAS) events, covering 22 human tissues. SASdb reveals extensive sex-specific splicing patterns, offering new insights into molecular sex differences. A case study on NSCLC-specific SAS events, absent in healthy tissues, highlights their enrichment in cancer-related pathways like autophagy, GPI-anchor biosynthesis, and AMPK/mTOR signaling. SASdb’s intuitive visualization supports research in sex biology and precision medicine.

The online version contains supplementary material available at 10.1186/s13293-026-00861-5.