# Integrating Case-Based Learning (CBL) and Concept Mapping (CM) enhances learning outcomes in medical biochemistry

**Authors:** Taimei Zhou, Haiying Wang, Xinglin Jiang

PMC · DOI: 10.1186/s12909-026-08906-4 · BMC Medical Education · 2026-02-26

## TL;DR

Combining case-based learning and concept mapping in teaching medical biochemistry improves student performance and is highly appreciated for its effectiveness and practical benefits.

## Contribution

This study demonstrates the effectiveness of integrating case-based learning with concept mapping in medical biochemistry education.

## Key findings

- Students in the CBL- and CM-based program scored significantly higher on final exams than those in traditional lectures.
- Students rated the CBL-CM approach highly for improving logical thinking and connecting basic science to clinical practice.
- The innovative program received overwhelmingly positive feedback with an overall preference score of 4.93 out of 5.

## Abstract

Teaching biochemistry poses significant challenges in undergraduate medical education. Case-based learning (CBL) and concept mapping (CM) are two widely recognized instructional strategies in medical education. This study aimed to integrate CBL with CM in biochemistry teaching and evaluate the combined effects of these strategies on medical students' learning outcomes, compared to traditional didactic lectures.

This study included 60 second-year medical students from Hunan University of Medicine (China) in their first semester. Participants were randomly assigned to two groups: a control group (n = 30) that received traditional didactic lectures, and an innovation group (n = 30) that participated in a CBL- and CM-based program. A final examination and Likert-scale questionnaires were used to evaluate the effectiveness and potential advantages of the innovative approach compared to conventional lectures.

Students who participated in the innovative program achieved significantly higher final examination scores than those who received traditional didactic lectures. The majority of students enjoyed using CBL combined with CM, with their overall preference for this combined approach scoring 4.93 out of 5. Notably, the highest-rated aspect (4.97/5) was the combination's effectiveness in enhancing logical thinking abilities, while its role in bridging the gap between basic science and clinical practice also received a high score of 4.83/5.

The innovative program integrating CBL and CM not only led to higher academic performance compared to the traditional course but also received overwhelmingly positive feedback from students. They particularly valued the combined use of CBL and CM for enhancing their logical thinking skills and bridging the gap between basic science and clinical practice.

## Full-text entities

- **Diseases:** CBL (MESH:D007859), Ketoacidosis (MESH:D007662), metabolic disorders (MESH:D008659), DKA (MESH:D016883), insulin deficiency (MESH:D007333), metabolic acidosis (MESH:D000138), Diabetes (MESH:D003920), anxiety (MESH:D001007), acid-base disturbance?5 (MESH:D000137), coma (MESH:D003128), hyperglycemia (MESH:D006943), CM (MESH:C535477)
- **Chemicals:** acetone (MESH:D000096), fatty acid (MESH:D005227), CBL (-), acetoacetate (MESH:C016635), beta-hydroxybutyrate (MESH:D020155), glucose (MESH:D005947), ketones (MESH:D007659), TCA (MESH:D014238), Ketone Body (MESH:D007657), acetyl-CoA (MESH:D000105)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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Source: https://tomesphere.com/paper/PMC13040744