# An ATM–AMPK–Wip1 feedback loop governing DNA-damage signaling and tumor stress responses

**Authors:** Shantanu Gupta, Pritam Kumar Panda

PMC · DOI: 10.1038/s41419-026-08599-z · Cell Death & Disease · 2026-03-17

## Full-text entities

- **Genes:** MAPK14 (mitogen-activated protein kinase 14) [NCBI Gene 1432] {aka CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2}, PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2) [NCBI Gene 5563] {aka AMPK, AMPK2, AMPKa2, PRKAA}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D) [NCBI Gene 8493] {aka IDDGIP, JDVS, PP2C-DELTA, WIP1}, STK11 (serine/threonine kinase 11) [NCBI Gene 6794] {aka LKB1, PJS, hLKB1}, MDM2 (MDM2 proto-oncogene) [NCBI Gene 4193] {aka ACTFS, HDMX, LSKB, hdm2}, CAMKK2 (calcium/calmodulin dependent protein kinase kinase 2) [NCBI Gene 10645] {aka CAMKK, CAMKKB}, ATM (ATM serine/threonine kinase) [NCBI Gene 472] {aka AT1, ATA, ATC, ATD, ATDC, ATE}, PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1) [NCBI Gene 5562] {aka AMPK, AMPK alpha 1, AMPKa1}
- **Diseases:** toxicity (MESH:D064420), cancers (MESH:D009369), Cell (MESH:D002292)
- **Chemicals:** lactate (MESH:D019344), AMP (MESH:D000249), ROS (-), ATP (MESH:D000255)

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Source: https://tomesphere.com/paper/PMC13039940