# Case Report: A case of giant left ventricular aneurysm resulting in LAD compression and stenosis

**Authors:** Qun Wang, Longyu Li, Wenhua Lin

PMC · DOI: 10.3389/fcvm.2026.1754121 · Frontiers in Cardiovascular Medicine · 2026-03-18

## TL;DR

A 67-year-old man with heart failure had a large left ventricular aneurysm that compressed a heart artery, showing how such aneurysms can actively cause new heart problems.

## Contribution

This case highlights the rare complication of a giant left ventricular aneurysm causing dynamic coronary artery compression and emphasizes the role of advanced imaging in diagnosis.

## Key findings

- A giant left ventricular aneurysm caused dynamic mid-LAD stenosis through extrinsic compression.
- Multimodal imaging confirmed extensive scar tissue covering 69% of the left ventricle.
- The case illustrates a feedback loop of ischemia and ventricular remodeling due to the aneurysm.

## Abstract

We present the case of a 67-year-old male smoker who developed progressive heart failure despite successful primary PCI for an acute extensive anterior ST-elevation myocardial infarction. Initial echocardiography revealed an apical left ventricular aneurysm (LVA). Readmission 40 days later showed dramatic ventricular dilation, severely reduced LVEF (19%), and a large inferoapical aneurysm. Multimodality imaging was pivotal: repeat angiography demonstrated a new dynamic mid-LAD stenosis; IVUS confirmed extrinsic luminal compression without plaque; CMR and nuclear scintigraphy quantified extensive scar (69% of LV). This comprehensive workup excluded conventional causes and established a diagnosis of external mechanical compression of the mid-LAD by the expanding giant LVA, creating a vicious cycle of ischemia and remodeling. This case underscores that an LVA is not merely a passive scar but can be a dynamically disruptive entity. It highlights the critical role of advanced imaging in diagnosing this rare complication and illustrates the therapeutic dilemma when definitive surgery is declined.

## Linked entities

- **Diseases:** heart failure (MONDO:0005252), ST-elevation myocardial infarction (MONDO:0041656)

## Full-text entities

- **Diseases:** aneurysm (MESH:D000783), LAD (MESH:C535887), smoker (MESH:C000719328), ischemia (MESH:D007511), stenosis (MESH:D003251), myocardial infarction (MESH:D009203), ventricular dilation (MESH:C566255), LVA (MESH:D018487), heart failure (MESH:D006333)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13039096/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC13039096/full.md

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Source: https://tomesphere.com/paper/PMC13039096