# Cardiac surgery in an infant hemophilia B carrier with moderate hemophilia: a case report

## TL;DR

A 4-month-old girl with moderate hemophilia B and a heart defect successfully underwent complex cardiac surgery using a long-lasting clotting factor.

## Contribution

First reported case of complex cardiac surgery in an infant hemophilia B carrier using extended half-life factor IX.

## Key findings

- Extended half-life recombinant factor IX (rFIX-FP) enabled stable coagulation during surgery.
- The patient experienced no excessive bleeding and recovered well post-surgery.
- Interdisciplinary collaboration and individualized planning are crucial for such cases.

## Abstract

This is the first reported case of a female infant with moderate hemophilia B undergoing complex cardiac surgery, highlighting challenges in managing bleeding disorders in this rare clinical setting.

A 4-month-old girl with Trisomy 21 was found to have moderate hemophilia B and an atrioventricular septal defect requiring surgery.

Genetic testing confirmed hemophilia B. Surgery was performed successfully using extended half-life recombinant factor IX (rFIX-FP) to maintain stable coagulation. The patient experienced no excessive bleeding and recovered well.

This case demonstrates that extended half-life FIX products enable safe and effective management of moderate hemophilia B during complex cardiac surgery in infants. Individualized perioperative planning and interdisciplinary collaboration are essential for optimal outcomes.