# The role of thrombospondin-1 in dermatological conditions

## TL;DR

This review explores how thrombospondin-1 influences skin diseases by affecting processes like inflammation and tumor growth, highlighting its potential as a treatment target.

## Contribution

The paper systematically reviews THBS1's molecular mechanisms in skin conditions, emphasizing its role as a therapeutic target.

## Key findings

- THBS1 modulates key skin disease processes like angiogenesis and fibrosis.
- It plays a central role in wound healing and tissue regeneration.
- THBS1 signaling is implicated in inflammatory responses and tumor progression in the skin.

## Abstract

Thrombospondin-1 (THBS1) is a multifunctional extracellular matrix protein that interacts with various cell surface receptors, including cluster of differentiation 36 (CD36), CD47, and integrins, as well as secreted proteins such as angiogenic factors and transforming growth factor (TGF)-β. THBS1 drives the development of various skin diseases at the molecular level by modulating core pathological processes, such as angiogenesis, fibrosis, inflammation, and tumor progression, thereby serving as a pivotal nexus between fundamental research and clinical dermatology. This review systematically explores the molecular mechanisms of THBS1 signaling in the skin, highlighting its implications in wound healing, tissue regeneration, inflammatory responses, fibrosis, and skin tumor development. By examining these aspects, we aim to elucidate the multifaceted roles of THBS1 in clinically refractory skin diseases and its translational potential as a therapeutic target.