# Case Report: Marchiafava-Bignami disease: anti-parietal cell antibodies as a potential etiological factor in a novel case presentation

## TL;DR

This case report explores a rare neurological disease and suggests a new possible cause related to antibodies and vitamin B12 deficiency.

## Contribution

The paper introduces a novel case linking anti-parietal cell antibodies to Marchiafava-Bignami disease.

## Key findings

- Anti-parietal cell antibodies may contribute to Marchiafava-Bignami disease.
- Vitamin B12 assessment is important in diagnosing MBD cases without thiamine deficiency.
- Early diagnosis and treatment are crucial for better clinical outcomes.

## Abstract

Marchiafava-Bignami disease (MBD) represents a rare neurological disorder predominantly associated with chronic ethanol consumption and thiamine insufficiency. However, its possible correlation with cobalamin deficiency resulting from anti-parietal cell antibodies (APCA) remained inadequately characterized in the literature. Timely diagnosis and therapeutic intervention were critical for optimizing clinical outcomes. This case suggested that APCA screening and vitamin B12 assessment should be considered in the diagnostic workup of MBD, especially in patients without classic thiamine deficiency.