# The impact of cardiac resynchronization therapy on diastolic parameters and mitral regurgitation: echocardiographic analysis of ultrasound-based left ventricular endocardial pacing system

## TL;DR

This study shows that a new pacing system improves heart function and reduces regurgitation in patients who couldn't benefit from traditional therapy.

## Contribution

The WiSE-CRT system's impact on diastolic function and mitral regurgitation is evaluated for the first time.

## Key findings

- Diastolic function and mitral regurgitation improved significantly after six months of WiSE-CRT therapy.
- Improvements were observed in both ischemic and non-ischemic cardiomyopathy subgroups.
- The system also improved left ventricular volumes and ejection fraction as previously reported.

## Abstract

The WiSE-CRT system offers an innovative approach to biventricular pacing in individuals who previously were considered too high risk or had failed traditional transvenous CRT therapy. The impact on LV volumes and systolic function have previously been published. This study evaluates the impact of the WiSE CRT system on diastolic filling parameters and mitral regurgitation.

Retrospective cohort study of patients in SOLVE-CRT with device implantation, activated CRT therapy, and a 6-month follow-up TTE. Baseline and 6-month parameters of diastolic function and mitral regurgitation were evaluation. Most patients had sufficient data for analysis. A sub-group analysis examined results in ischemic and non-ischemic cardiomyopathies.

Individual parameters of diastolic function and mitral regurgitation trended towards improvement at 6-months. Summative classification of diastolic function and mitral regurgitation both showed statistically significant improvement at 6-months follow-up (p < 0.01).

In addition to the established improvement in LV volumes and LV EF, patients with the WiSE-CRT biventricular pacing system demonstrate improvement in aggregate assessment of diastolic function and mitral regurgitation at 6-months.