# The evolving landscape of large language models and non-large language models in health care

**Authors:** Rui Yang, Huitao Li, Matthew Yu Heng Wong, Yuhe Ke, Xin Li, Kunyu Yu, Jingchi Liao, Jonathan Chong Kai Liew, Sabarinath Vinod Nair, Jasmine Chiat Ling Ong, Irene Li, Douglas Teodoro, Chuan Hong, Yifan Peng, Daniel Shu Wei Ting, Nan Liu

PMC · DOI: 10.1038/s44401-026-00076-1 · npj health systems · 2026-04-01

## TL;DR

This study compares large language models and traditional methods in healthcare, showing each excels in different tasks.

## Contribution

The paper identifies complementary strengths of LLMs and non-LLMs in healthcare through task distribution analysis.

## Key findings

- LLMs excel in open-ended tasks in healthcare applications.
- Non-LLM methods are more effective for information extraction tasks.
- The two approaches show complementary strengths in healthcare contexts.

## Abstract

We analyzed 19,123 natural language processing-related studies to explore the differences in task distributions and application contexts between large language models (LLMs) and non-LLM methods in health care. Through topic modeling analysis, we found that LLMs demonstrate advantages in open-ended tasks, while non-LLM methods dominate in information extraction tasks. These findings highlight the complementary strengths of the two technical paradigms and provide reference for their integration strategies in future health care applications.

## Full-text entities

- **Diseases:** Mental (MESH:D008607), LLMs (MESH:D007806)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13038296/full.md

## References

32 references — full list in the complete paper: https://tomesphere.com/paper/PMC13038296/full.md

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Source: https://tomesphere.com/paper/PMC13038296