High-resolution imaging techniques to interrogate virus-host interactions

TL;DR

This review discusses how high-resolution imaging techniques are transforming our understanding of how viruses interact with host cells.

Contribution

The paper highlights the latest imaging technologies that are enabling new insights into virus-host interactions.

Findings

High-resolution imaging is revealing novel mechanisms of viral assembly and host cell manipulation.

Live-cell imaging has uncovered unique aspects of virus-host interactions.

Advanced imaging techniques are enhancing the ability to study essential cell biological processes.

Abstract

Viruses are obligate parasites that rely extensively on host cellular machinery to complete their life cycles. Therefore, examining the fundamental nature behind how viruses interact with their hosts can teach us more about the pathogenesis of these microbes while also contributing to our overall understanding of essential cell biological processes. In a 2021 mSphere of Influence article, the use of live-cell imaging to uncover a unique mechanism of viral assembly was discussed. In this Full Circle review, we highlight the high-resolution imaging techniques currently revolutionizing virology research and discuss how they can be utilized to advance our ability to identify and interrogate novel virus-host interactions.