mSphere of Influence: The power of in situ—structural biology without leaving “home”
Nicholas A. Wood
TL;DR
This article discusses the impact of in situ structural biology in microbiology and reflects on tools like AlphaFold and open questions in the field.
Contribution
The article provides a reflective analysis of in situ structural biology's potential and challenges in microbiology.
Findings
In situ structural biology offers unique insights into protein structures within their native microbiological environments.
AlphaFold has limitations in capturing the full complexity of microbial systems.
Cross-disciplinary approaches can enhance structural biology research in microbiology.
Abstract
Nicholas A. Wood works in the field of biophysics with an emphasis on in situ protein structures in microbiological systems. In this mSphere of Influence article, he reflects on the power and limitations of AlphaFold, open questions in structural biology, and the cross-disciplinary potential of microbiological training.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsBacterial Genetics and Biotechnology · Protein Structure and Dynamics · Enzyme Structure and Function