High-power dual-channel chamber for high-frequency magnetic neuromodulation
Xiaoyang Tian, Hui Wang, Boshuo Wang, Jinshui Zhang, Dong Yan, Jeannette Ingabire, Samantha Coffler, Guillaume Duret, Quoc-Khanh Pham, Gang Bao, Junzhe Wang, Ashok Veeraraghavan, Jacob T Robinson, Stefan M Goetz, Angel V Peterchev
TL;DR
A new high-power magnetic chamber was developed to study how high-frequency magnetic fields can control neural activity in freely moving mice.
Contribution
The novel dual-channel magnetic chamber enables independent, high-frequency magnetic stimulation with real-time behavioral observation.
Findings
The system generates two orthogonal magnetic fields at 50 and 550 kHz with minimal interference.
The chamber maintains uniform magnetic field distribution and safe temperature increases during operation.
Frequency-selective heating was demonstrated using doped and undoped nanoparticles.
Abstract
Objective. Several novel methods, including magnetogenetics and magnetoelectric stimulation, use high frequency alternating magnetic fields to precisely manipulate neural activity. To quantify the behavioral effects of such interventions in a freely moving mouse, we developed a dual-channel magnetic chamber, specifically designed for rate-sensitive magnetothermal-genetic stimulation, and adaptable for other uses of alternating magnetic fields. Approach. Through an optimized coil design, the system allows independent control of two spatially orthogonal uniform magnetic fields delivered at different frequencies within a 10 × 10 × 6 cm3 chamber suitable for mouse studies. The two channels have nominal frequencies of 50 and 550 kHz with peak magnetic field strengths of 88 and 12.5 mT, achieved with resonant coil drives having peak voltages of 1.6 and 1.8 kV and currents of 1.0 and 0.26 kA,…
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Taxonomy
TopicsTranscranial Magnetic Stimulation Studies · Electromagnetic Fields and Biological Effects · Functional Brain Connectivity Studies