Association between a novel nutritional index and coronary heart disease in COPD patients: a retrospective study in China

TL;DR

A new nutritional index called TCBI is linked to a lower risk of heart disease in COPD patients in China.

Contribution

The study introduces TCBI as a novel nutritional index associated with coronary heart disease in COPD patients.

Findings

Each 100-unit increase in TCBI was linked to a significantly lower likelihood of CHD in COPD patients.

RCS analysis showed a linear relationship between TCBI and CHD in COPD patients.

Age ≥ 60 years modified the association between TCBI and CHD in COPD patients.

Abstract

Chronic obstructive pulmonary disease (COPD) commonly coexists with coronary heart disease (CHD). This retrospective study aimed to examine the association between the triglyceride-total cholesterol-body mass index (TCBI) and the CHD in COPD patients.

This study included 407 participants recruited from the Second Affiliated Hospital of Chongqing Medical University. Logistic regression models were employed to evaluate the association between TCBI and CHD among hospitalized COPD patients undergoing coronary angiography for chest pain. Restricted cubic spline (RCS) analysis was conducted to investigate potential non-linear relationships. Additionally, subgroup analyses were performed to identify variations across different population groups.

The study included 407 participants with a median age of 72 years. After adjusting After adjustment for covariates, each 100-unit increase in TCBI was associated with a significantly lower likelihood of CHD in COPD patients (odds ratio [OR] = 0.927; 95% confidence interval [CI], 0.879–0.976; P = 0.004). RCS analysis demonstrated a linear relationship between TCBI and CHD in COPD patients (P = 0.021; P-nonlinear = 0.986). Subgroup analysis revealed that age ≥ 60 years significantly modified the association between TCBI and CHD in COPD patients (OR = 0.999; 95% CI: 0.998–0.999; P < 0.001).

This study suggests a significant association between TCBI and CHD in COPD patients, which may cause selection bias only for this population. Future investigations should validate these findings through well-designed longitudinal studies and multiethnic cohort analyses across diverse populations to enhance the robustness and generalizability of the results.

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