# Cosmeceuticals in acne vulgaris: from mechanism of action to clinical application

## TL;DR

This paper reviews how cosmeceuticals can help treat acne by reducing side effects and improving treatment compliance.

## Contribution

The paper provides a comprehensive review of cosmeceuticals for acne, highlighting evidence for specific ingredients like retinol and BPO.

## Key findings

- Topical retinol, benzoyl peroxide, and azelaic acid have the strongest clinical evidence for acne treatment.
- Cosmeceuticals can reduce side effects like dryness and erythema from traditional acne treatments.
- More large-scale human trials are needed to validate cosmeceutical efficacy in severe acne.

## Abstract

The use of cosmeceuticals in acne vulgaris is becoming increasingly prevalent with many over-the-counter formulations becoming part of patients’ routine skincare. Cosmeceuticals are often used successfully as an adjunctive therapy to reduce the side effects of traditional prescriptions and improve compliance. This is a review to support the use of cosmeceuticals in acne, including retinol, retinaldehyde, benzoyl peroxide (BPO), azelaic acid, beta hydroxy acids, alpha hydroxy acids, niacinamide, zinc, tea tree oil and green tea. There is most evidence, in human clinical trials, to support the use of topical retinol, BPO and azelaic acid. Further research with large-scale robust human clinical trials are required to go beyond in vitro studies. Most research has focused on mild-to-moderate acne and few studies have looked at the use of cosmeceuticals in more severe acne. Overall, adjunctive treatment with cosmeceuticals might reduce the side effect profile of standard therapies such as dryness, itching, scaling and erythema, promoting treatment compliance and improving acne outcomes.

The use of cosmeceuticals in acne vulgaris is becoming increasingly prevalent with many over-the-counter formulations becoming part of patients’ routine skincare. Cosmeceuticals are often used successfully as an adjunctive therapy to reduce the side-effects of traditional prescriptions and improve compliance. This is a review to support the use of cosmeceuticals in acne including: retinol, retinaldehyde, benzoyl peroxide, azelaic acid, beta hydroxy acids, alpha hydroxy acids, niacinamide, zinc, tea tree oil and green tea.