One-year outcome trends in Japanese patients with rosacea: insights from a real-world study

TL;DR

A study tracked Japanese rosacea patients over a year, finding gradual improvement in symptoms and quality of life, with insights into ethnic and gender differences.

Contribution

The study provides new insights into long-term rosacea outcomes in Japanese patients, highlighting ethnic-specific trends and symptom progression.

Findings

Subjective symptoms like itch and burning sensation significantly improved over one year.

Quality of life scores (DLQI) and objective assessments (IGA) showed time-dependent improvement.

Sex differences were observed in the clinical course of certain symptoms.

Abstract

Rosacea is a chronic inflammatory disorder that primarily affects the facial region, significantly impacting quality of life (QOL). Outcomes in patients with rosacea may vary significantly depending on ethnicity, climatic conditions, healthcare system and cultural background. After unifying these factors, outcomes in rosacea should be evaluated over the long term.

To examine long-term outcomes in Japanese patients with rosacea using data obtained from a single institution.

In this retrospective observational study, data from 63 Japanese patients with rosacea, including 42 patients who were followed up over 1 year, were analysed. Patients were treated with topical agents, with or without oral minocycline, and advised to avoid common triggers such as sun exposure and skin dryness. These data were evaluated using the Dermatology Life Quality Index (DLQI), visual analogue scale (VAS) and Investigator’s Global Assessment (IGA) scoring systems.

Baseline data for the 63 patients showed that QOL was commonly impaired by uncomfortable sensations, such as itch, as well as by disfigurement. Most patients considered rosacea to have a small-to-moderate impact on their lives. DLQI scores were significantly correlated with VAS scores for itch, burning sensation, flushing and hypersensitivity. IGA scores were significantly correlated with VAS scores for flushing and with DLQI scores. Follow-up data for 42 patients over 1 year showed that VAS scores for itch, burning sensation, flushing and hypersensitivity, as well as DLQI and IGA scores, were significantly decreased over time. Topical therapies did not affect the scores throughout the clinical course.

This study was conducted at a single institution in a specific geographical and climatic setting for Japanese patients with rosacea. These findings may inform follow-up care for Japanese patients and contribute to the exploration of ethnic and geographical variations in the presentation and progression of rosacea.

This study was conducted at a single institution within a specific geographic and climatic setting to evaluate long-term trends in rosacea outcomes among Japanese patients. One-year follow-up data initially revealed (i) a significant, time-dependent improvement in both subjective symptoms affecting quality of life and objective findings and (ii) sex differences in the clinical course of certain subjective symptoms. These findings may help guide follow-up care for Japanese patients and contribute to understanding ethnic variations in rosacea.

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