# Orthognathic surgery-related nerve injuries: analysis and treatment modalities

**Authors:** Yaara Yaniv-Klein, Nadav Grinberg, Amir Shuster, Clariel Ianculovici, Shlomi Kleinman, Reema Mahmoud, Oren Peleg

PMC · DOI: 10.22514/jofph.2026.023 · 2026-03-12

## TL;DR

This study examines nerve injuries after orthognathic surgery and evaluates treatment outcomes, suggesting low-level laser therapy may help recovery.

## Contribution

The study provides real-world data on incidence and treatment of trigeminal nerve injuries after orthognathic surgery.

## Key findings

- 17 nerve injuries were identified in 287 patients based on postoperative sensory complaints.
- Low-level laser therapy (LLLT) showed potential therapeutic benefits for neurosensory recovery.
- Complete neurosensory recovery remains challenging despite various treatment modalities.

## Abstract

Background: Orthognathic surgery, while highly effective in correcting 
dentofacial deformities, inherently poses a risk of neurosensory complications. 
Despite the growing volume of these surgical procedures, real-world data remain 
limited concerning the precise incidence, clinical course, and efficacy of 
various therapeutic interventions for nerve injuries in this specific context. 
This study aims to delineate the incidence, anatomical distribution, and 
treatment outcomes of trigeminal nerve injuries observed after orthognathic 
surgery within a tertiary care center. Methods: This retrospective 
cohort study involved 287 patients who underwent orthognathic surgical 
procedures. Data, including demographic, surgical, and follow-up course, were 
extracted from electronic medical records. Nerve injuries were specifically 
identified based on documented postoperative sensory complaints localized to the 
distribution of the maxillary (CN V2) or mandibular (CN V3) divisions of the 
trigeminal nerve. Data regarding post-operative treatment using different 
modalities were collected and analyzed. Results: Our 
retrospective review identified 17 nerve injuries based on documented 
postoperative sensory complaints within the CN V2 or CN V3 distributions. The 
various treatment modalities employed included low-level laser therapy (LLLT), 
corticosteroids, and vitamin B supplementation. Detailed outcomes regarding the 
incidence and distribution of these injuries were analyzed. Conclusions: 
Post-orthognathic surgery trigeminal neurosensory deficits, while not common, are 
clinically significant. Our findings suggest that LLLT may offer a therapeutic 
advantage in managing these deficits, though achieving complete neurosensory 
recovery remains a challenge.

## Full-text entities

- **Diseases:** mandibular deformities (MESH:D008336), weakness (MESH:D018908), pain (MESH:D010146), infra-orbital nerve deficit (MESH:D009916), temporomandibular joint disorders (MESH:D013705), nasal deformities (MESH:D009668), hypoesthesia (MESH:D006987), edema (MESH:D004487), sciatic nerve injury (MESH:D020426), neuropathy (MESH:D009422), nerve deficits (MESH:D001289), inflammation (MESH:D007249), sensory damage (MESH:D009477), Postoperative (MESH:D019106), Neurosensory deficit (MESH:D006319), sensory  disturbances (MESH:D012678), BSSO (MESH:D003398), deformities (MESH:D009140), sensory loss (MESH:C580162), injuries (MESH:D014947), paresthesia (MESH:D010292), infection (MESH:D007239), hemorrhage (MESH:D006470), IAN (MESH:D000080902), dentofacial deformities (MESH:D063169), trigeminal neurosensory deficit (MESH:D020433), jaw and facial  deformities (MESH:D007571), paralysis (MESH:D010243), trigeminal injury (MESH:D061221), Le (MESH:C535314)
- **Chemicals:** Vitamin B12 (MESH:D014805), Steroids (MESH:D013256), dexamethasone (MESH:D003907), B3 (MESH:C053396), niacinamide (MESH:D009536), Thiamine (MESH:D013831), B12 (MESH:C034730), Pyridoxine (MESH:D011736), methylcobalamin (MESH:C019476), B6 (-), Riboflavin (MESH:D012256), B2 (MESH:C023970)
- **Species:** Homo sapiens (human, species) [taxon 9606], Rattus norvegicus (brown rat, species) [taxon 10116]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13036608/full.md

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Source: https://tomesphere.com/paper/PMC13036608