# Periodontal therapy among patients with cardiovascular disease: exploring its association with lower medical spending

**Authors:** Morgan Santoro, Caroline McLeod, Lisa J. Heaton, Hannah J. Cheung, John J. O’Malley, Madison Vinson, Rebecca A. Preston, Eric P. Tranby

PMC · DOI: 10.3389/fpubh.2026.1741942 · 2026-03-17

## TL;DR

Treating periodontal disease in people with cardiovascular disease may lower overall medical costs, especially with four or more dental visits.

## Contribution

This study shows that periodontal treatment is associated with reduced healthcare spending in patients with cardiovascular disease.

## Key findings

- Patients with four or more periodontal visits had a 9.6% reduction in overall medical costs.
- Outpatient costs were reduced by 5.3% for patients with four or more periodontal visits.
- Patients with 1–3 periodontal visits had an 8% reduction in prescription costs.

## Abstract

Cardiovascular disease (CVD) and periodontal disease are prevalent chronic conditions that share common risk factors and may be linked through systemic inflammation. Emerging evidence suggests that individuals with periodontal disease are more likely to be diagnosed with CVD, potentially influencing health care costs.

This study analyzed deidentified commercial insurance claims data from 192,500 United States (U. S.) adults aged 21–64 with CVD diagnoses between 2015 and 2022. Patients were categorized based on periodontal treatment received in 2020–2021: none, 1–3 visits, or 4 + visits. Gamma regression and multinomial propensity score matching (PSM) models assessed associations between periodontal treatment and 2022 health care costs (overall, outpatient, inpatient, and prescription), controlling for demographic and clinical covariates. Reported percentage reductions and average treatment effect on treated (ATET) dollar difference reflect estimates derived from PSM-weighted models.

Patients with four or more periodontal visits had significantly lower overall medical costs (9.6% reduction; ATET = −$1,960.39, 95% confidence interval (CI) = −$2,684.33, −$1,236.44, p < 0.005) and outpatient costs (5.3% reduction; ATET = −$599.09, 95% CI = −$1,019.34, −$178.84, p < 0.005) compared to those without treatment. Patients with 1–3 visits had an 8% reduction in prescription costs (ATET = −$387.53, 95% CI = −$653.31, −$119.75, p < 0.005). Gamma regression analyses confirmed these associations after adjusting for confounders.

Findings suggest that periodontal treatment may be associated with lower health care costs among individuals with CVD, potentially attributed to reduced systemic inflammation. The cost differences were most pronounced with four or more periodontal visits, supporting risk-based recall strategies. These results underscore the relevance of integrating oral health into chronic disease management and indicate that greater access to periodontal care may be associated with economic and health benefits.

## Linked entities

- **Diseases:** cardiovascular disease (MONDO:0004995), periodontal disease (MONDO:0002635)

## Full-text entities

- **Diseases:** inflammation (MESH:D007249), systemic (MESH:D015619), CVD (MESH:D002318), periodontal disease (MESH:D010510), disease (MESH:D004194)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13036156/full.md

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Source: https://tomesphere.com/paper/PMC13036156