Plasmablast, memory B cell and T follicular helper cell responses after human papillomavirus vaccination: effect of dose number and age
Eunice W. Kiamba, Dolapo O. Ajiboye, Adedapo Olufemi Bashorun, Mamie Ndeban Jallow, Lamin Drammeh, Samba Bah, Tijan Jobarteh, Francis Kanu, Ousubie Jawla, Jobarteh Lamin, Anne Segonds-Pichon, Martin J. Holland, Martin R. Goodier, Sophie Roetynck, Ed Clarke
TL;DR
This study examines how HPV vaccination affects immune responses in Gambian females, focusing on B cells and T follicular helper cells across different doses and ages.
Contribution
The study reveals how multi-dose HPV vaccination enhances specific immune cell responses compared to single-dose regimens.
Findings
HPV16/18-specific IgM plasmablasts increased after the first dose, while IgG responses required multiple doses.
T follicular helper cell activation varied with age and dose number.
Multi-dose schedules may better sustain antibody protection through coordinated immune responses.
Abstract
Multiple doses of HPV vaccines induce durable, antibody-mediated protection against HPV infections and HPV-associated diseases. Although actual protection against disease by a single HPV vaccination dose has not been confirmed in randomised trials, this regimen induces protection against incident and persistent HPV infection, similar to multi-dose schedules. However, the cellular mechanisms driving durable antibody responses to subunit vaccines remain poorly understood. B cells and T follicular helper (Tfh) cells play central roles in long-term antibody-mediated immunity. We characterised plasmablast, memory B cell (Bmem), and Tfh cell responses to assess the effects of dose number and age following HPV vaccination in Gambian females aged 4–26 years. A significant induction of HPV16/18-specific IgM plasmablasts occurred after the first dose, while robust HPV16/18-specific IgG…
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Taxonomy
TopicsCervical Cancer and HPV Research · Immunotherapy and Immune Responses · Immune responses and vaccinations