Polymorphic low-grade neuroepithelial tumor of the young and treatment of epilepsy: a case report

TL;DR

A 6-year-old boy with a rare brain tumor and uncontrolled seizures was successfully treated with surgery, showing that tumor removal can help control epilepsy.

Contribution

This case report demonstrates that surgical resection of PLNTY can effectively control epilepsy when combined with comprehensive preoperative evaluation.

Findings

Surgical resection of PLNTY led to no epileptic seizures during 6 months of follow-up.

Multimodal imaging and electrocorticography helped guide the successful resection of the lesion.

Comprehensive preoperative evaluation is crucial for effective treatment of PLNTY with epilepsy.

Abstract

Polymorphic low-grade neuroepithelial tumor of the young (PLNTY) is a rare central nervous system tumor. Clinical manifestations often start with seizures, and the lesions are often located in the superficial parts of the cerebral hemisphere, especially in the temporal lobe. Patients with PLNTY can be cured via surgical treatment, but whether the seizure can be controlled by simply removing the tumor through surgery still needs to be determined.

The patient was a 6-year-old boy with clinical manifestations of recurrent epileptic seizures. Preoperative standardized antiepileptic drug treatment failed to control seizures. The patient’s electroencephalogram showed was right parietal and central regions is the main slow wave and spike slow wave emitting area, and Magnetic Resonance Imaging s(MRI) showed was structural abnormalities in the right parietal lobe cortex. After multidisciplinary preoperative evaluation at the epilepsy center of Tianjin Children’s Hospital, lesion enlargement resection was performed with the assistance of multimodal imaging and electrocorticography (ECoG) monitoring. There were no epileptic seizures during the 6-month follow-up after surgery.

For this patient with PLNTY accompanied by epilepsy, surgical resection can be the first line of treatment. Meanwhile, a comprehensive multidisciplinary preoperative evaluation should be conducted. Additionally, appropriate enlargement and resection can effectively eliminate epileptic seizures.

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