# The microbiome: regulating anti-tumor immunity

**Authors:** Yan-Lin Tao, Xin-Xin Wu, Jing-Ran Wang, Miao Liu, Ya-Nan Liu, Yong-Qi Lian, Zhao-Yu Liang, Shu-Fen Zhu

PMC · DOI: 10.3389/fimmu.2026.1781872 · Frontiers in Immunology · 2026-03-17

## TL;DR

This paper discusses how the microbiome influences anti-tumor immunity and explores new treatment strategies targeting it.

## Contribution

The paper provides an updated analysis of the microbiome's role in tumor progression and novel therapeutic approaches.

## Key findings

- The microbiome regulates immune function during tumor development.
- Dysregulated microorganisms affect treatment response and toxicity in tumors.
- Cutting-edge strategies targeting the microbiome show promise for cancer treatment.

## Abstract

Microorganisms distributed throughout the human body have always been a complex ecosystem that has long coexisted with other organisms. They are involved in essential key links, such as nutrient absorption, energy regulation, metabolism, toxin clearance, and immune regulation. With a deeper understanding of the microbiome, many studies have shown that the microbiome is also actively involved in the occurrence and development of tumors. The core mechanism of dysregulated microorganisms and their derivatives in the treatment response and toxicity management of tumors is the regulation of the immune function. This article explores the evolution of the microbiome and its impact on the immune function during tumor progression, and focuses on analyzing cutting-edge treatment strategies targeting the microbiome, as well as future research directions and challenges in clinical translation.

## Full-text entities

- **Diseases:** toxicity (MESH:D064420), tumor (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13035494/full.md

## References

88 references — full list in the complete paper: https://tomesphere.com/paper/PMC13035494/full.md

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Source: https://tomesphere.com/paper/PMC13035494