# Neuroblastoma in neonates: a case report and literature review

## TL;DR

This paper reports two rare cases of cervical neuroblastoma in neonates and discusses their surgical treatment and outcomes.

## Contribution

The novelty lies in describing two distinct surgical approaches and outcomes for neonatal cervical neuroblastoma with detailed clinical observations.

## Key findings

- Two neonates with cervical neuroblastoma presented with stridor and feeding difficulties due to tumor compression.
- Surgical resection was successful in one case, while the second case showed no capsule formation and arterial involvement.
- Neither patient developed Horner’s syndrome or showed recurrence after 10 months.

## Abstract

Neuroblastoma in neonates is a rare solid tumor. This report presents two rare cases of cervical neuroblastoma, both characterized by stridor and coughing during feeding due to tumor compression. The first case of neuroblastoma presented with an intact capsule, allowing for complete surgical resection with preservation of the cervical vasculature and nerves. In contrast, although preoperative MRI indicated an intact capsule in the second case, the intraoperative findings revealed no discernible capsule formation and involvement of both the internal and external carotid arteries. None of the two patients developed Horner’s syndrome postoperatively, and no evidence of recurrence or metastasis has been observed during the 10-month follow-up period. These cases also underscore that surgical intervention remains the primary treatment option for cervical neuroblastoma, particularly in alleviating the respiratory and feeding difficulties caused by tumor compression.