# Agreement between a swept-source optical coherence tomography and dual Scheimpflug Placido analyser in healthy, keratoconus suspect and keratoconus eyes

## TL;DR

This study compares two eye imaging devices for measuring corneal parameters in healthy and keratoconus eyes, finding they are not interchangeable.

## Contribution

The study evaluates device agreement in normal, keratoconus suspect, and keratoconus eyes using statistical and Bland–Altman analysis.

## Key findings

- Devices showed wide limits of agreement in normal eyes for most parameters.
- Pachymetric measurements consistently differed between devices.
- ANTERION reported smaller central corneal thickness values than GALILEI G4.

## Abstract

To evaluate the agreement and interchangeability of anterior and posterior corneal parameters measured by the swept-source optical coherence tomography–based ANTERION and the dual Scheimpflug–Placido GALILEI G4 in normal, keratoconus suspect (KS), and keratoconus (KC) eyes.

In this cross-sectional study, 221 eyes (129 normal, 40 KS, 52 KC) were examined using ANTERION and GALILEI G4 in a single session. Anterior and posterior keratometry (K1, K2, K Max), best-fit sphere (BFS), central corneal thickness (CCT), and minimum corneal thickness (MCT) were analysed. Inter-device agreement was assessed using paired statistical tests and Bland–Altman analysis.

In normal eyes, most parameters showed statistically significant mean differences with wide limits of agreement (LoA). In KS eyes, no significant differences were observed in each parameter. In KC eyes, mean differences were minimal, though LoAs were wide, particularly for anterior keratometry and pachymetry; only MCT showed a statistically significant difference. Pachymetric measurements consistently differed between devices, with ANTERION generally reporting smaller values.

The wide LoAs between ANTERION and GALILEI indicate that the devices are not interchangeable, particularly for longitudinal monitoring in keratoconus. Consistent use of a single device is recommended in clinical practice.