# Peristomal pyoderma gangrenosum: a review of nursing research progress

**Authors:** Guowei Chen, Xiaoxu Lan, Fang Li, Deyuan Zeng, Luhong Wang, Xiaoyu Chen, Li Zhu

PMC · DOI: 10.3389/fmed.2026.1774931 · Frontiers in Medicine · 2026-03-16

## TL;DR

This paper reviews the nursing research on peristomal pyoderma gangrenosum, a rare inflammatory skin condition affecting stoma patients, focusing on diagnosis, treatment, and care strategies.

## Contribution

The paper provides a comprehensive nursing-focused review of PPG, emphasizing multidisciplinary care and future research directions.

## Key findings

- PPG is linked to immune dysfunction, genetic factors, and surgical trauma.
- Effective management requires a combination of wound care, systemic therapies, and nursing support.
- Future research should target biomarkers and standardized nursing protocols for PPG.

## Abstract

Peristomal pyoderma gangrenosum (PPG) is a rare and therapeutically challenging inflammatory dermatosis predominantly affecting individuals with stoma surgery. This review provides a comprehensive overview of PPG, encompassing its etiology, clinical manifestations, diagnostic methods, treatment strategies, and nursing management. PPG’s multifactorial etiology involves immune dysfunction, genetic predisposition, surgical trauma, and demographic factors, which contribute to the formation of painful ulcers that significantly impair patients’ quality of life. Accurate diagnosis requires a multidisciplinary approach, including clinical evaluation, histopathological examination, and advanced diagnostic criteria. Effective management combines local wound care, systemic therapies, and surgical interventions, emphasizing a patient-centered and evidence-based approach. Nursing strategies, including advanced wound care, pain management, psychological support, nutritional interventions, and health education, play a vital role in optimizing outcomes and preventing recurrence. Future research should focus on the development of specific biomarkers, novel therapeutic agents, and standardized nursing protocols to address the unmet needs in PPG care. This integrated diagnostic, therapeutic, and nursing framework aims to enhance patient outcomes and provide insights for future clinical and research advancements.

## Linked entities

- **Diseases:** pyoderma gangrenosum (MONDO:0018824)

## Full-text entities

- **Diseases:** trauma (MESH:D014947), PPG (MESH:D017511), ulcers (MESH:D014456), inflammatory dermatosis (MESH:D012871), immune (MESH:D007154), pain (MESH:D010146)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13033744/full.md

## References

38 references — full list in the complete paper: https://tomesphere.com/paper/PMC13033744/full.md

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Source: https://tomesphere.com/paper/PMC13033744