Identification and validation of the potential therapeutic value of CASK in osteosarcoma: a computational analysis and in vitro experiments
Hongjuan Yang, Weiying Zhong, Danping Shen, Sihui Chen
TL;DR
This study explores CASK's role in osteosarcoma, showing it may be a new target for treatment by affecting cancer cell growth and immune responses.
Contribution
The study identifies CASK as a novel potential therapeutic target in osteosarcoma through computational and experimental validation.
Findings
CASK is significantly upregulated in osteosarcoma samples.
Inhibiting CASK promotes apoptosis and inhibits cell cycle progression in osteosarcoma cells.
CASK is linked to immune processes and the JAK/STAT signaling pathway, particularly with Macrophages_M2.
Abstract
Currently, identifying new therapeutic targets in clinical practice is crucial for improving the treatment of osteosarcoma. The abnormal expression of calcium/calmodulin-dependent serine protein kinase (CASK) plays an important role in the tumorigenesis of many cancers; however, the role of CASK in the potential therapeutic value of osteosarcoma has not been reported. The Gene Expression Omnibus (GEO) database was used to analyze the expression levels of CASK in osteosarcoma patients. Cell experiments validated the role of CASK in osteosarcoma cells and revealed the potential mechanism of action of CASK from three aspects: immunity, pathogenic gene expression, and protein interaction. The results showed that CASK was significantly upregulated in osteosarcoma samples. Inhibiting the expression of CASK can significantly promote cell apoptosis and inhibit the cycle progression of…
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Taxonomy
TopicsHippo pathway signaling and YAP/TAZ · Melanoma and MAPK Pathways · Nuclear Structure and Function