Solid lipid nanoparticles enhance piracetam’s neuroprotective action in streptozotocin-induced cognitive dysfunction
Abhishek Mishra, Bhabani Sankar Satapathy, Pratap Kumar Sahu
TL;DR
This study shows that piracetam, a drug repurposed into solid lipid nanoparticles, improves cognitive function in diabetic rats better than the drug alone.
Contribution
The novel contribution is the development and evaluation of piracetam-loaded solid lipid nanoparticles for treating diabetes-induced cognitive dysfunction.
Findings
PSLNs improved memory and behavior in diabetic rats compared to plain piracetam and controls.
PSLNs showed higher drug retention and accumulation in the brain, as indicated by improved pharmacokinetic parameters.
Histopathology showed restored brain tissue architecture in PSLN-treated rats.
Abstract
Diabetes-induced cognitive dysfunction remains an unaddressed medical concern across the globe with limited options left with conventional drug therapy. Piracetam, the first identified nootropic agent has been repurposed in the current study via solid-lipid nanoparticle against streptozotocin-induced cognitive dysfunction in rats. Experimental piracetam loaded solid-lipid nanoparticles (PSLNs) were developed by conventional nanoprecipitation method and characterized in terms of SEM, AFM, DLS, zeta potential, drug loading efficiency etc. In vivo efficacy of the selected PSLNs was analysed. Various biochemical parameters were analysed along with histopathology and brain pharmacokinetic studies. Experimental PSLNs were spherical, nanosized, homogenous (PDI: 0.21 ± 0.5) with − 38.2 ± 0.3 mV surface charge. Following administration, selected PSLNs brought significant improvement in…
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Taxonomy
TopicsAdvanced Drug Delivery Systems · Neurological Disease Mechanisms and Treatments · Medicinal Plants and Neuroprotection