# Localized Bullous Pemphigoid Triggered by Surgical Trauma: A Case Highlighting the Koebner Phenomenon

**Authors:** Marwa Faik Ouahab, Soumiya Chiheb, Awatef Kelati

PMC · DOI: 10.7759/cureus.104408 · 2026-02-27

## TL;DR

An elderly woman developed bullous pemphigoid along a surgical scar, showing how skin trauma can trigger this autoimmune skin condition.

## Contribution

This case highlights the Koebner phenomenon in bullous pemphigoid triggered by surgical trauma.

## Key findings

- Localized bullous pemphigoid developed along a surgical scar one month after orthopedic surgery.
- Histology and immunofluorescence confirmed the diagnosis of bullous pemphigoid.
- Topical corticosteroid therapy led to clinical improvement.

## Abstract

Bullous pemphigoid (BP) is the most common autoimmune blistering disease in the elderly. Although usually spontaneous, it may be triggered by skin trauma. We report the case of a 90-year-old woman who developed localized BP along a surgical scar one month after orthopedic surgery. Lesions later spread to the trunk. Histology revealed a subepidermal blister with eosinophils, and immunofluorescence confirmed C3 deposition in addition to circulating anti-BP180 antibodies. Clinical improvement was observed following the initiation of topical corticosteroid therapy.

## Linked entities

- **Diseases:** bullous pemphigoid (MONDO:0019082)

## Full-text entities

- **Genes:** COL17A1 (collagen type XVII alpha 1 chain) [NCBI Gene 1308] {aka BA16H23.2, BP180, BPA-2, BPAG2, ERED, JEB4}
- **Diseases:** autoimmune blistering disease (MESH:D001768), skin trauma (MESH:D012871), Trauma (MESH:D014947), BP (MESH:D010391)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13033396/full.md

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Source: https://tomesphere.com/paper/PMC13033396