# Effects of transcranial photobiomodulation on performance and cardiovascular responses in trained cyclists

**Authors:** Tommaso Arrighi, Andrea Meloni, Giulia Zaccaria, Annalisa Prato, Antonio La Torre, Livio Luzi, Roberto Codella, Luca Filipas

PMC · DOI: 10.3389/fphys.2026.1766916 · 2026-03-16

## TL;DR

This study found that transcranial photobiomodulation did not improve cycling performance or physiological responses in trained cyclists.

## Contribution

The study provides empirical evidence that acute PBM does not enhance endurance performance in trained athletes.

## Key findings

- No significant effects of PBM on heart rate, lactate, or perceived exertion were observed.
- PBM did not improve performance in constant-load or time-trial cycling tests.
- The PBM parameters used may not be sufficient to influence cortical or performance outcomes.

## Abstract

Transcranial photobiomodulation (PBM) has been proposed to enhance prefrontal cortex (PFC) oxygenation and modulate central mechanisms of fatigue, potentially improving endurance performance. This study investigated the acute effects of PBM on cycling time-trial (TT) performance in well-trained cyclists.

In a randomized, double-blind, crossover design, 18 trained cyclists completed two experimental conditions (PBM and SHAM) prior to a constant-load (CL) test at 5% above the first lactate threshold (LT1) and a 25-min self-paced TT on their own bicycles mounted on an ergometer.

No significant condition × time interactions were found for heart rate, blood lactate, ratings of perceived exertion (RPE), or power-related ratios during either the constant-load or TT trials (p > 0.05).

Acute transcranial PBM did not influence cycling performance or perceptual and physiological responses in trained athletes. These findings suggest that the applied PBM parameters may have been insufficient to elicit measurable cortical or performance effects. Future research should explore optimized stimulation parameters and chronic application protocols to clarify the potential ergogenic role of PBM in endurance exercise.

## Full-text entities

- **Diseases:** fatigue (MESH:D005221)
- **Chemicals:** lactate (MESH:D019344)

## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13033375/full.md

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Source: https://tomesphere.com/paper/PMC13033375