# A single next generation sequencing assay for detection of driver mutations, rearrangements and copy number abnormalities in plasma cell dyscrasias

**Authors:** Cecilia Bonolo de Campos, Daniela Trujillo, James Smadbeck, Mariano Arribas, Hongwei Tang, Neeraj Sharma, Gregory J. Ahmann, Shaji K. Kumar, A. Keith Stewart, Rafael Fonseca, P. Leif Bergsagel, Yan W. Asmann, Linda B. Baughn, Esteban Braggio

PMC · DOI: 10.1038/s41408-026-01482-2 · 2026-03-28

## Full-text entities

- **Genes:** ATM (ATM serine/threonine kinase) [NCBI Gene 472] {aka AT1, ATA, ATC, ATD, ATDC, ATE}, IGK (immunoglobulin kappa locus) [NCBI Gene 50802] {aka IGK@}, IGH (immunoglobulin heavy locus) [NCBI Gene 3492] {aka IGD1, IGH.1@, IGH@, IGHD@, IGHDY1, IGHJ}, DIS3 (DIS3 exosome endoribonuclease and 3'-5' exoribonuclease) [NCBI Gene 22894] {aka 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p}, HLA-G (major histocompatibility complex, class I, G) [NCBI Gene 3135] {aka MHC-G}, NSD2 (nuclear receptor binding SET domain protein 2) [NCBI Gene 7468] {aka KMT3F, KMT3G, MMSET, RAUST, REIIBP, TRX5}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, IGHD (immunoglobulin heavy constant delta) [NCBI Gene 3495], NRAS (NRAS proto-oncogene, GTPase) [NCBI Gene 4893] {aka ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6}, MYC (MYC proto-oncogene, bHLH transcription factor) [NCBI Gene 4609] {aka MRTL, MYCC, bHLHe39, c-Myc}, BRAF (B-Raf proto-oncogene, serine/threonine kinase) [NCBI Gene 673] {aka B-RAF1, B-raf, BRAF-1, BRAF1, NS7, RAFB1}, TENT5C (terminal nucleotidyltransferase 5C) [NCBI Gene 54855] {aka FAM46C}, SDC1 (syndecan 1) [NCBI Gene 6382] {aka CD138, SDC, SYND1, syndecan}, KRAS (KRAS proto-oncogene, GTPase) [NCBI Gene 3845] {aka 'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A}, IGL (immunoglobulin lambda locus) [NCBI Gene 3535] {aka IGL@}
- **Diseases:** plasma cell malignancy (MESH:D054219), MGUS (MESH:D008998), genetic abnormalities (MESH:D030342), SV (MESH:D020914), plasma cell dyscrasias (MESH:D010265), CNV (OMIM:610141), monosomy (MESH:D009006), tumor (MESH:D009369), number abnormalities (MESH:D007674), SMM (MESH:D000075122), H-MM (MESH:D009101)
- **Chemicals:** creatinine (MESH:D003404)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13032923/full.md

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Source: https://tomesphere.com/paper/PMC13032923