# Impact of individualized colored spectacle filters on photophobia and visual comfort in central visual field defect patients: a one-year study

**Authors:** Margarita Krasniakova, Tony Pansell, Jörgen Gustafsson

PMC · DOI: 10.1038/s41598-026-45302-w · 2026-03-26

## TL;DR

This study shows that personalized colored glasses can improve visual comfort and reduce light sensitivity in patients with central vision loss over a year.

## Contribution

The study introduces individualized colored spectacle filters as a long-term solution for photophobia and visual discomfort in specific eye conditions.

## Key findings

- Patients with Leber Hereditary Optic Neuropathy experienced notable reduction in photophobia symptoms.
- Blue-green colored filters were most preferred and improved subjective visual comfort.
- Personalized tinted spectacles showed trends in enhancing visual function and comfort over time.

## Abstract

Visual comfort is a critical yet often overlooked aspect in managing patients with central visual field defects and photophobia. This study investigates the long-term effects of individualized colored spectacle filters on visual comfort and function in patients with Age-related Macular Degeneration and Leber Hereditary Optic Neuropathy. Patients were fitted with individualized precision tint spectacles tailored to improve vision comfort for one year. The study involved a comprehensive evaluation of visual acuity, contrast sensitivity, and photophobia symptoms alongside qualitative feedback from patient interviews. Results indicate significant improvements in subjective visual comfort and function, with a notable reduction in photophobia symptoms among patients with Leber Hereditary Optic Neuropathy. Colored filters, particularly those in the blue-green spectrum, were preferred by most patients and had a positive impact on comfort. Statistical analysis revealed trends in color preferences and subjective enhancements in visual function, underscoring the potential benefits of comfort-tint filters and the importance of personalized treatment approaches. The findings suggest that individualized colored spectacle filters can be valuable in enhancing visual comfort and function for patients with central visual field defects. This study shows the importance of integrating visual comfort considerations into clinical practice for a comprehensive approach to patient care.

## Linked entities

- **Diseases:** Age-related Macular Degeneration (MONDO:0005150), Leber Hereditary Optic Neuropathy (MONDO:0010788)

## Full-text entities

- **Genes:** OPN4 (opsin 4) [NCBI Gene 94233] {aka MOP}
- **Diseases:** low (MESH:D009800), Central visual field reduction (MESH:D014786), migraine (MESH:D008881), eye disease (MESH:D005128), accommodative- and convergence dysfunction (MESH:D009759), corneal dystrophy (MESH:D003317), AMD (MESH:D008268), errors (MESH:D012030), blepharospasm (MESH:D001764), low vision (MESH:D015354), field (MESH:D007922), brain fatigue (MESH:D005221), chronic ocular pain (MESH:D059350), LHON (MESH:D029242), cataract (MESH:D002386), Photophobia (MESH:D020795), diabetic retinopathy (MESH:D003930), dizziness (MESH:D004244), ophthalmic disorders (MESH:C535922), keratoconus (MESH:D007640), mitochondrial (MESH:D028361), cognitive impairment (MESH:D003072), pain (MESH:D010146), Hereditary Optic Neuropathy (MESH:D015418)
- **Chemicals:** FL-41 (-), CR-39 (MESH:C028827)
- **Species:** Rattus norvegicus (brown rat, species) [taxon 10116], Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** CIE UCS — Tachysurus ussuriensis (Ussuri catfish), Spontaneously immortalized cell line (CVCL_1G59)

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13031931/full.md

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Source: https://tomesphere.com/paper/PMC13031931