Sensitive voltammetric detection of bosentan using gold nanoparticles-decorated pencil graphite electrode in pharmaceutical formulations and plasma samples
Yossra A. Trabik, Reham A. Ismail, Miriam F. Ayad, Lobna A. Hussein, Amr M. Mahmoud
TL;DR
A new eco-friendly electrochemical sensor using gold nanoparticles on a pencil graphite electrode was developed to detect bosentan in pharmaceuticals and plasma with high accuracy.
Contribution
The study introduces a sensitive and green electrochemical method for bosentan detection using gold nanoparticle-modified electrodes.
Findings
The sensor achieved a dynamic range of 2.5 × 10−7 to 2.5 × 10−5 M with a detection limit of 7.92 × 10−8 M.
The method was validated for accuracy and precision in pharmaceutical dosage forms and human plasma.
The analytical method received a high greenness score of 78.0 and an AGREE score of 0.65.
Abstract
In this study, a new eco-friendly electrochemical sensor was effectively designed and utilized to analyze bosentan (BOS); an endothelin receptor antagonist (ERA) that helps in the management of pulmonary artery hypertension (PAH), in its pharmaceutical dosage forms and in human plasma samples. Our approach involves BOS electro-oxidation on a gold nanoparticles- modified pencil graphite electrode (PGE) surface in order to improve electrode sensitivity and increase peak current. Gold nanoparticles (Au-NPs) were electrochemically deposited onto the electrode surface using cyclic voltammetry (CV). With the aid of differential pulse voltammetry, a quantitative determination of BOS was obtained in 0.1 M KCl across a potential range of 0.00 to 1.8 V. The method’s validation was performed in compliance with International Council for Harmonization of Technical Requirements for Pharmaceuticals…
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Taxonomy
TopicsElectrochemical sensors and biosensors · Dye analysis and toxicity · Paraquat toxicity studies and treatments