# Unveiling Uncommon: Perforated Peptic Ulcer Mimicking Post-Cesarean Complications—A Case Report

**Authors:** Samantha Davis, Samie A. Rizvi, Moosa Malik, Mostafa E. Nagy, Hani Serag

PMC · DOI: 10.3390/reports9010092 · Reports - Clinical Practice and Surgical Cases · 2026-03-22

## TL;DR

A rare case of peptic ulcer perforation was misdiagnosed as a post-cesarean complication, highlighting the need for broader diagnostic approaches in similar cases.

## Contribution

This case report adds to the understanding of atypical post-cesarean complications and emphasizes the importance of considering non-gynecologic causes.

## Key findings

- A 27-year-old woman presented with symptoms resembling post-cesarean complications but was diagnosed with a 3 cm perforated peptic ulcer.
- Misdiagnosis as gastroenteritis led to emergency laparotomy and successful omental patch repair.
- The case underscores the need to consider non-gynecologic causes for persistent post-cesarean abdominal symptoms.

## Abstract

Background and Clinical Significance: Peptic ulcer perforation is a severe complication of peptic ulcer disease, resulting from erosion of the upper gastrointestinal mucosa. While uncommon in post-cesarean patients, its symptoms can resemble post-operative complications, risking delayed diagnosis and adverse outcomes. This case highlights the need for an expanded diagnostic approach in post-cesarean patients with atypical abdominal symptoms. Case Presentation: A 27-year-old West African woman presented to Ain Shams University Hospital in Cairo, Egypt, with worsening abdominal pain, vomiting, fever, and tachycardia three weeks post-cesarean. Initially misdiagnosed with gastroenteritis, she underwent emergency laparotomy due to persistent symptoms, which revealed a 3 cm perforated peptic ulcer. An omental patch repair was performed, and she was discharged in stable condition seven days later. Peptic ulcer perforation, although rare post-cesarean, can mimic common post-operative symptoms, leading to diagnostic delays. A thorough evaluation of abdominal symptoms unresponsive to standard post-operative care is essential, as misdiagnosis increases risks of morbidity. Non-gynecologic causes should be considered, particularly with persistent symptoms. Conclusions: Physicians should consider peptic ulcer perforation in post-cesarean patients presenting with sustained abdominal pain, fever, or gastrointestinal distress. Recognizing atypical complications early allows timely intervention, improving outcomes and reducing mortality. This case underscores the value of broad differential diagnoses in post-operative care.

## Linked entities

- **Diseases:** peptic ulcer perforation (MONDO:0004260), peptic ulcer disease (MONDO:0004247), gastroenteritis (MONDO:0002269)

## Full-text entities

- **Genes:** EGF (epidermal growth factor) [NCBI Gene 1950] {aka HOMG4, URG}, GAST (gastrin) [NCBI Gene 2520] {aka GAS}, COX1 (cytochrome c oxidase subunit I) [NCBI Gene 4512] {aka COI, MTCO1}, AOC1 (amine oxidase copper containing 1) [NCBI Gene 26] {aka ABP, ABP1, DAO, DAO1, KAO, KDAO}, SST (somatostatin) [NCBI Gene 6750] {aka SMST, SST1}, COX8A (cytochrome c oxidase subunit 8A) [NCBI Gene 1351] {aka COX, COX8, COX8-2, COX8L, MC4DN15, VIII}, SLC17A5 (solute carrier family 17 member 5) [NCBI Gene 26503] {aka AST, ISSD, NSD, SD, SIALIN, SIASD}
- **Diseases:** edema (MESH:D004487), gastroenteritis (MESH:D005759), vomiting (MESH:D014839), inflammatory (MESH:D007249), mucosal injury (MESH:D052016), fever (MESH:D005334), bowel injury (MESH:D012778), H. pylori infection (MESH:D016481), systemic illness (MESH:D012140), rebound tenderness (MESH:D063806), chronic (MESH:D002908), sepsis (MESH:D018805), organ failure (MESH:D009102), PUD (MESH:D010437), hypovolemic shock (MESH:D012769), pneumoperitoneum (MESH:D011027), dehydration (MESH:D003681), gastrointestinal disease (MESH:D005767), dyspepsia (MESH:D004415), gastrointestinal distress (MESH:D012128), tachycardia (MESH:D013610), chronic gastritis (MESH:D005756), perforated (MESH:D057112), febrile (MESH:D000071072), rigidity (MESH:D009127), acute abdomen (MESH:D000006), pain (MESH:D010146), gastric perforation (MESH:D013274), intra-abdominal perforation (MESH:D000082122), mucosal disease (MESH:D004194), aspiration (MESH:D011015), peritonitis (MESH:D010538), PPU (MESH:D010439), hypotensive (MESH:D007022), Ulcer (MESH:D014456), septic shock (MESH:D012772), injury (MESH:D014947), ileus (MESH:D045823), abdominal pain (MESH:D015746)
- **Chemicals:** bicarbonate (MESH:D001639), histamine (MESH:D006632), bilirubin (MESH:D001663), Metronidazole (MESH:D008795), sodium (MESH:D012964), creatinine (MESH:D003404), potassium (MESH:D011188), alcohol (MESH:D000438), Ceftriaxone (MESH:D002443), progesterone (MESH:D011374), Lactate (MESH:D019344), prostaglandin (MESH:D011453), over-the-counter medications (-)
- **Species:** Helicobacter pylori (species) [taxon 210], Homo sapiens (human, species) [taxon 9606], Nicotiana tabacum (American tobacco, species) [taxon 4097]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13030677/full.md

## References

21 references — full list in the complete paper: https://tomesphere.com/paper/PMC13030677/full.md

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Source: https://tomesphere.com/paper/PMC13030677