# Paediatric Snakebite Toxicity up to Compartment Syndrome: A Ten-Year Retrospective Study in Iasi, Romania

**Authors:** Bogdan Caba, Sidonia Petronela Susanu, Ioana Cezara Caba, Tamara Roșu-Solange, Bogdan Huzum, Vasile Eduard Roșu, Ileana Katerina Ioniuc, Maria Adriana Mocanu, Iuliana Magdalena Starcea

PMC · DOI: 10.3390/toxins18030128 · Toxins · 2026-03-02

## TL;DR

This study examines viper bites in children in Romania over ten years, highlighting the importance of timely treatment to prevent severe complications like compartment syndrome.

## Contribution

The study provides a detailed retrospective analysis of pediatric viper bite cases, emphasizing the need for multidisciplinary treatment to improve outcomes.

## Key findings

- 83.33% of viper bites occurred on the lower limb in pediatric patients.
- One case evolved into compartment syndrome and required fasciotomy to save the limb.
- Multidisciplinary treatment, including antivenom and selective fasciotomy, improves functional prognosis.

## Abstract

Viper bites are medical emergencies that can develop into serious clinical complications and can endanger the life of the paediatric patient. This observational retrospective study analyses 24 cases of viper bites involving paediatric patients (<18 years) encountered over 10 years (2016–2025) in the emergency department of Saint Mary Emergency Hospital of Iasi, Romania, with a focus on those requiring specialised surgical monitoring. Sociodemographic factors, toxicity, and surgical management of snakebites were analysed. In 83.33% cases, viper bites were found on the lower limb. The retrospective study was completed through an in-depth analysis of two representative cases, with a particular focus on the evolution up to compartment syndrome. Of the 24 cases presented in the Emergency Department, one was a rare and severe case, which evolved into compartment syndrome and required fasciotomy to save the limb in the Plastic Surgical Department. Another one, with the bite localised at the upper limb, had perilesional oedema, without skin colour changes or secretions, preservation of joint contours, and normal nail colouration. Both were analysed and described in detail with all available data (images, investigations, etc.) to highlight pathophysiological and therapeutic aspects. Appropriate, multidisciplinary treatment considerably improves the functional prognosis of patients with viper bites; administration of antivenom and selective fasciotomy contribute to successful outcomes. The study emphasises that viper bites in children remain a public health problem in Romania and require prompt and multidisciplinary treatment.

## Linked entities

- **Diseases:** compartment syndrome (MONDO:0004001)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, IGHE (immunoglobulin heavy constant epsilon) [NCBI Gene 3497] {aka IgE}, FGB (fibrinogen beta chain) [NCBI Gene 2244] {aka HEL-S-78p}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha) [NCBI Gene 5286] {aka CPK, OCSKD, PI3-K-C2(ALPHA), PI3-K-C2A, PI3K-C2-alpha, PI3K-C2alpha}
- **Diseases:** ecchymosis (MESH:D004438), lymphangitis (MESH:D008205), Kounis Syndrome (MESH:D000074962), ischaemia (MESH:D007511), tachycardia (MESH:D013610), Compartment Syndrome (MESH:D003161), ischaemic damage (MESH:D018917), myoglobinuria (MESH:D009212), neurotoxic (MESH:D020258), muscle damage (MESH:D009133), systemic (MESH:D015619), pain (MESH:D010146), muscle ischaemia (MESH:D019042), reactive thrombocytosis (MESH:D013922), Cardiovascular complications (MESH:D002318), myocarditis (MESH:D009205), cytotoxic (MESH:D064420), hypotension (MESH:D007022), death (MESH:D003643), tetanus (MESH:D013746), bleeding (MESH:D006470), anaemia (MESH:D000743), infection (MESH:D007239), Cerebral and myocardial infarction (MESH:D002544), Oedema (MESH:C536897), injury to (MESH:D014947), myotoxicity (MESH:D000081030), insect (MESH:C000719201), metabolic acidosis (MESH:D000138), rhabdomyolysis (MESH:D012206), anaphylactic reaction (MESH:D000707), acute inflammation (MESH:D007249), viperine syndrome (MESH:D013577), renal failure (MESH:D051437), Ludwig's Angina (MESH:D008158), thrombocytopenia (MESH:D013921), allergic reactions (MESH:D004342), vomiting (MESH:D014839), skin necrosis (MESH:D012871), angioedema (MESH:D000799), swelling (MESH:D004487), Bite Wound (MESH:D001733), Snakebite Toxicity (MESH:D012909), neutrophilia (MESH:C563010), necrosis (MESH:D009336), pulmonary oedema (MESH:D011654), poisoning (MESH:D011041), impotence (MESH:D007172), airway blockage (MESH:D015508), diarrhoea (MESH:D003967), tissue loss (MESH:D017695), ketosis (MESH:D007662), neurological damage (MESH:D020196), hypofibrinogenemia (MESH:D000347), Coagulation disorders (MESH:D001778), blisters (MESH:D001768), cellulitis (MESH:D002481), dehydration (MESH:D003681), vascular destruction (MESH:D008105), muscle necrosis (MESH:D009135)
- **Chemicals:** ketone bodies (MESH:D007657), ammodytase (-), glucose (MESH:D005947), SC (MESH:D012538), ascorbic acid (MESH:D001205), bilirubin (MESH:D001663)
- **Species:** Vipera ammodytes (sand viper, species) [taxon 8704], Homo sapiens (human, species) [taxon 9606], Vipera berus (adder, species) [taxon 31155], Vipera ursinii (species) [taxon 103942], Bos taurus (bovine, species) [taxon 9913], Vipera berus berus (common viper, subspecies) [taxon 31156], Equus caballus (domestic horse, species) [taxon 9796], Bitis caudalis (horned adder, species) [taxon 8693]

## Full text

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## Figures

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## References

34 references — full list in the complete paper: https://tomesphere.com/paper/PMC13030228/full.md

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Source: https://tomesphere.com/paper/PMC13030228