# The Significance of a Mushroom Diet in the Prevention of Osteoporosis

## TL;DR

Eating mushrooms may help prevent osteoporosis by supporting bone health through nutrients like vitamin D and minerals.

## Contribution

This paper systematically reviews mushroom species and their potential role in preventing osteoporosis through diet.

## Key findings

- Mushrooms contain vitamin D and minerals that support bone formation and remineralization.
- UV-irradiated mushrooms can increase vitamin D2 content, enhancing their preventive potential for osteoporosis.
- Species like Lentinula edodes and Ganoderma lucidum show promise in promoting bone regeneration.

## Abstract

Osteoporosis is a metabolic disease of the skeleton characterized by a low bone mass and deterioration of bone tissue structure, leading to increased fragility and susceptibility to fractures. It is often referred to as the “silent killer of bones” because it progresses without symptoms until a bone fracture occurs. Osteoporosis is a serious health problem, especially in aging societies, leading to fractures, limited mobility, and a decreased quality of life. Osteoporosis prevention through dietary modification should be the first step in protecting bone health before implementing any form of pharmacotherapy. The composition of the diet and nutritional patterns are considered the most important factors influencing the shaping of gut microbiota and its metabolites, which in turn affect the regulation of bone tissue metabolism. Mushrooms, as a source of vitamin D, can play a significant role in the prevention of osteoporosis. Additionally, the application of UV irradiation can rapidly increase the vitamin D2 content in mushrooms. A review of currently available studies reveals that many mushroom species contain substances (Ca, P, Se) that support bone formation by promoting remineralization. Mushrooms also induce bone regeneration after osteoporosis by balancing their reconstruction. This review systematically integrates the latest research on the use of mushrooms in the prevention of osteoporosis. The most promising species in the prevention of osteoporosis include: Lentinula edodes, Ganoderma lucidum, Ophiocordyceps sinensis, Pleurotus eryngii, Antrodia camphorata, Auricularia auricula, Agaricus bisporus, and Grifola frondosa.