# Herbal Textual Research, Phytochemistry, Pharmacology and Toxicity of Atractylodis Rhizoma: A Comprehensive Review

## TL;DR

This review explores the history, chemical makeup, and health benefits of Atractylodis Rhizoma, highlighting its potential for treating gastrointestinal and flu-related issues.

## Contribution

The paper provides a comprehensive overview of AR's phytochemistry and pharmacology, identifying research gaps and suggesting future directions.

## Key findings

- AR contains 327 compounds, including sesquiterpenes and flavonoids, linked to antimicrobial and anti-inflammatory effects.
- AR shows therapeutic potential for modern gastrointestinal disorders and influenza.
- Future research should focus on multi-omics and molecular biology to improve understanding and bioavailability.

## Abstract

This review examines the historical development, ethnopharmacology, traditional applications, phytochemistry, and pharmacological attributes of Atractylodis Rhizoma (AR). Data were collected from a range of electronic databases, academic libraries, and classical literature. In China, AR is highly valued for its medicinal properties. Research has identified 327 compounds, including sesquiterpenes, triterpenes, flavonoids, and phenolics, which contribute to its diverse pharmacological activities, such as antimicrobial, anti-inflammatory, antioxidant, hepatoprotective, and neuroprotective effects. AR is particularly effective in treating modern gastrointestinal disorders and influenza. As a traditional herb with a rich historical background, AR exhibits significant therapeutic potential. This review aims to correlate its active components with its primary therapeutic effects and highlight existing research gaps. Current studies primarily focus on extraction methods and pharmacodynamics. Future research should employ multi-omics and molecular biology techniques to further elucidate active components and their targets, while also addressing the challenge of low bioavailability.