# Anti-Inflammatory Activity of Cyclic Imide Derivatives

## TL;DR

This review explores the anti-inflammatory and other therapeutic properties of cyclic imide derivatives, including their analgesic, anticancer, and cholesterol-lowering effects.

## Contribution

The paper provides a comprehensive overview of the diverse biological activities of cyclic imide derivatives, highlighting their potential in drug development.

## Key findings

- Cyclic imide derivatives show significant anti-inflammatory activity.
- Some derivatives also exhibit analgesic, anticancer, and antibacterial effects.
- Imide derivatives have reported neuroprotective and lipid-lowering properties.

## Abstract

Imide derivatives constitute an interesting group of compounds exhibiting broad biological activity. Structures containing the imide moiety [–CO–N(R)–CO–] occur in both natural and synthetic compounds. Several drugs containing an imide moiety are in therapeutic use. In this review, we present the structures and describe the effects of cyclic imide derivatives, which primarily exhibit anti-inflammatory activity. Some of the presented derivatives have been studied in detail, and their additional analgesic, anticancer, and antibacterial effects have been described. The relative neuroprotective properties of imide derivatives are also described, as are reports of their effect on lowering cholesterol and triglyceride levels. In this review, we discuss monocyclic imide derivatives (succinimide, glutarimide, maleimide, and hydantoin), bicyclic derivatives (e.g., phthalimide), and polycyclic imides.