# KSHV and Human Diseases: Beyond KS, PEL and MCD

## TL;DR

This paper reviews how Kaposi’s Sarcoma-associated herpesvirus (KSHV) may be linked to various diseases beyond known cancers, highlighting the need for further research.

## Contribution

The paper expands the known disease associations of KSHV, suggesting links to conditions like diabetes, malaria, and heart disease.

## Key findings

- KSHV is linked to Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease.
- Emerging evidence suggests KSHV may also be associated with diabetes, malaria, heart disease, and other cancers.
- More research is needed to understand the molecular mechanisms of KSHV-related diseases.

## Abstract

Kaposi’s Sarcoma-associated herpesvirus (KSHV) has been etiologically linked to several human cancers, including Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD). However, recent studies suggest that KSHV infection may also be associated with the development of other diseases or increased risks, such as KSHV inflammatory cytokine syndrome (KICS), diabetes, malaria, heart disease, and other cancers. In this review, we summarize these findings from clinical observations, epidemiological studies or laboratory research, though more studies are needed in these emerging areas. We believe that this work will enhance our understanding of the molecular mechanisms underlying KSHV pathogenesis and contribute to improving treatments for related human diseases.