# Biodegradable Nanoplastics: An Overlooked Polluting Terra Incognita Towards Global Plastic Risk Assessment?

**Authors:** Xiaowei Wu, Shuai Tang, Kun Lu, Xiaoli Zhao

PMC · DOI: 10.3390/nano16060371 · Nanomaterials · 2026-03-19

## TL;DR

This paper highlights the overlooked risks of biodegradable nanoplastics and calls for global action to assess and manage their environmental impact.

## Contribution

The paper introduces the need for a full-chain risk assessment system for biodegradable nanoplastics.

## Key findings

- Biodegradable nanoplastics' global occurrence and ecological risks are poorly understood due to lack of monitoring data.
- Current assumptions about the eco-friendliness of biodegradable nanoplastics are questionable.
- A coordinated global effort is needed to develop detection technologies and legal frameworks for biodegradable plastics.

## Abstract

To mitigate environmental plastic accumulation and close the loop on plastic, the development of biodegradable plastics has presented a promising prospect for overcoming the global plastic pollution issue. However, it is critical to examine not only their benefits but also their unintended ecological consequences, especially for smaller-sized biodegradable nanoplastics. Our work highlights the often-overlooked risks associated with biodegradable nanoplastics. Due to the lack of environmental in situ monitoring data, the global occurrence, fate, and ecological risk of biodegradable nanoplastics remain poorly understood. Likewise, it remains unclear and questionable whether nanoplastics are eco-friendly as a promising alternative to the circular and sustainable plastic economy. We, therefore, call for a coordinated global effort to proactively mitigate the potential risks of biodegradable nanoplastics, including establishing a full-chain risk assessment system, developing key detection and simulation technologies, designing and optimizing bioplastic structures, and improving the legal supervision mechanism. These holistic efforts will facilitate the development of a sustainable practice for the closed-loop recycling of biodegradable plastics, which simultaneously helps establish a sustainable biodegradable plastic circular economy.

## Full-text entities

- **Genes:** LIPF (lipase F, gastric type) [NCBI Gene 8513] {aka GL, HGL, HLAL}, CAT (catalase) [NCBI Gene 847], MMP12 (matrix metallopeptidase 12) [NCBI Gene 4321] {aka HME, ME, MME, MMP-12}, C5AR1 (complement C5a receptor 1) [NCBI Gene 728] {aka C5A, C5AR, C5R1, CD88}, C3 (complement C3) [NCBI Gene 718] {aka AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1}, PAM (peptidylglycine alpha-amidating monooxygenase) [NCBI Gene 5066] {aka PAL, PAM-1, PHM}, SOD1 (superoxide dismutase 1) [NCBI Gene 6647] {aka ALS, ALS1, HEL-S-44, IPOA, SOD, STAHP}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, ACHE (acetylcholinesterase (Yt blood group)) [NCBI Gene 43] {aka ACEE, ARACHE, N-ACHE, YT}
- **Diseases:** toxicity (MESH:D064420), neurotoxicity (MESH:D020258), hyperuricemia (MESH:D033461), inflammatory (MESH:D007249), neurodegenerative diseases (MESH:D019636), plastic pollution (MESH:D010411), injury to (MESH:D014947), nerve injury (MESH:D000080902)
- **Chemicals:** PP (MESH:D011126), PBS (MESH:C089797), microplastics (MESH:D000080545), chlorophyll (MESH:D002734), water (MESH:D014867), PHAs (MESH:D054813), imidacloprid (MESH:C082359), poly(butylenesuccinate-co-adipate (MESH:C574545), nitrogen (MESH:D009584), ester (MESH:D004952), polymer (MESH:D011108), Nanoplastics (-), PE (MESH:D020959), carbon (MESH:D002244), PLA (MESH:C033616), PBSA (MESH:C437084)
- **Species:** Homo sapiens (human, species) [taxon 9606], Eisenia fetida (brandling worm, species) [taxon 6396], Metaphire sieboldi (earthworm, species) [taxon 506672]
- **Cell lines:** Caco-2 — Homo sapiens (Human), Colon adenocarcinoma, Cancer cell line (CVCL_0025)

## Full text

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## Figures

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## References

29 references — full list in the complete paper: https://tomesphere.com/paper/PMC13029003/full.md

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Source: https://tomesphere.com/paper/PMC13029003