# Fermented Soybean Meal and Its Application in Animal Husbandry: A Review

**Authors:** Lina Tokuna Mulalapele, Lei Xu, Dongxu Ming, Yanpin Li, Wenjuan Sun, Xilong Li, Yu Pi

PMC · DOI: 10.3390/microorganisms14030691 · Microorganisms · 2026-03-19

## TL;DR

Fermented soybean meal improves animal feed efficiency by breaking down proteins into bioactive peptides that benefit gut health.

## Contribution

The paper identifies microbial proteolysis of glycinin into bioactive peptides as the key mechanism behind fermented soybean meal's benefits.

## Key findings

- Fermented soybean meal improves intestinal morphology and modulates gut microbiota through low-molecular-weight peptides.
- A 5–10% improvement in feed conversion ratio in swine offsets the fermentation processing cost.
- Standardization of solid-state fermentation protocols remains a challenge due to strain-specific metabolic pathways.

## Abstract

Soybean meal (SBM) is a foundational protein source, but its industrial application is constrained by a complex matrix of anti-nutritional factors (ANFs). This review provides a critical synthesis of the biochemical transition from raw SBM to fermented SBM (FSBM), focusing on the synergistic mechanisms of fungal and bacterial co-fermentation. We identify that the efficacy of FSBM is primarily driven by the microbial proteolysis of glycinin into low-molecular-weight bioactive peptides (<1000 Da). These peptides serve as the primary drivers for improved intestinal morphology (increased villus height) and the modulation of the gut microbiota, providing a mechanistic basis for reported probiotic effects. Furthermore, we establish that the 5–10% improvement in the feed conversion ratio (FCR) documented for swines mathematically offsets the processing premium of fermentation. However, critical gaps remain in the standardization of solid-state fermentation (SSF) protocols, specifically regarding the selection of fungal (Aspergillus) and bacterial (Bacillus or Lactobacillus) strains, whose distinct metabolic pathways significantly diversify the functional profile of the resulting FSBM.

## Linked entities

- **Proteins:** GY2 (glycinin subunit G2)
- **Species:** Aspergillus (taxon 5052), Bacillus (taxon 1386), Lactobacillus (taxon 1578)

## Full-text entities

- **Chemicals:** FSBM (-)
- **Species:** Bacillus (genus) [taxon 55087], Aspergillus (genus) [taxon 5052], Sus scrofa (pig, species) [taxon 9823], Lactobacillus (genus) [taxon 1578]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13028734/full.md

## References

133 references — full list in the complete paper: https://tomesphere.com/paper/PMC13028734/full.md

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Source: https://tomesphere.com/paper/PMC13028734